13종 항 경련제의 자살 유발 정도 비교 자살 형태 와 자살 이유 > 임상 응용 정보

13종 항 경련제의 자살 유발 정도 비교 자살 형태 와 자살 이유

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13종 항경련제들의 자살 유발 정도 비교 
 
자살 형태와 자살 이유</TD></TR>
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항견련제로 사용되는 약은 
 
Carbamazepine,
Oxycarbazepine,
Topiramate,
Gabapentine,계
Lamotrigine,
 Valproate,
Primidone 등  무려 13종이나 된다.
 
 
간질에도 사용 되지만
 
신경통에도 사용한다.
 
정신병 증상에도 사용한다.
 
 
이러한 항경련제가 자살을 유발한다는 사실은
 
이미 잘 알려진 사실이다
 
 
2008 미국 FDA에서도 
 
11가지 항경련제에 대해 자살 유발 가능성을 경고한 바 있다
 
 
 
하버드 의대 연구 팀은 
 
2001년부터 2006년까지 5년 사이에
 
항경련제를 복용한 297,620명을 대상으로 하여
 
자살을 시도했거나
 
자살로 사망했거나
 
폭력으로 사망한 자를 분석하고
 
이를 미국 의사 회 학술지 JAMA 최신호를 통해 
 
그 이유와 함께 발표하였다</TD></TR>
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2 배의 자살 율</TD></TR>
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미국 FDA는 아래 표에서처럼
 
모든 항경련제는 약을 사용안 하는 위약군에 비해
 
2배의 자살율을 나타낸다고 발표했었다.
 
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 </TD>
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복용 자</TD>
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복용 안한 자  </TD></TR>
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자살율(100명당) </TD>
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0.43</TD>
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0.22 </TD></TR></TBODY></TABLE>
 
 
그러나 본 연구에서는
 
항결련제 중에서 
 
간질 뿐 아니라 다른 적응증에 
 
많이 사용되는 Topiramate를 기준으로 하여
 
 자살 시도율과
 
 자살 사망율과
 
 폭력 사망율의 총 사건 발생 위험율을 비교 평가 했으며 
 
그 결과는 아래 표와 같다. 
 
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13종 항경련제의  자살시도, 자살사망, 폭력사망 
 
 유발 정도 비교 평가
 </TD></TR>
<TR>
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 </TD>
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약리 작용 </TD>
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약물 복용자
15세 이상</TD>
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6개월 간 
발생위험율</TD></TR>
<TR>
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 </TD>
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신경 전달 
억제 기전</TD>
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(2001-2006)
미국 15개주 </TD>
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Hazard
Ratio (HR)</TD></TR>
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(1)Oxcarbazepine</TD>
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Na 통로 억제
Ca 통로 억제</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
8,579</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
2.12</TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(2)Tiagabine</TD>
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Na 통로 억제
GABA 수용체 활성화</TD>
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5,497</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
2.40</TD></TR>
<TR>
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(3)Lamotrigine</TD>
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Na 통로 억제
Glutamate 억제</TD>
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22.256
 </TD>
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1.86</TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(4)Valproate</TD>
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GABA 수용체 활성화</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
18,295</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.69
 </TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(5)Levetiracetam</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Ca 통로억제
GABA수용체 활성화</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
3,975</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.66</TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(6)Phenobarbital</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
뇌감각피질 마비</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
2,130</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
0.96 </TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(7)Zonisamide</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Na 통로 억제
Ca 통로 억제</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
3,528</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.37</TD></TR>
<TR>
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(8)Carbamazepine</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Na 통로억제</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
9,859</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.19 </TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(9)Gabapentine</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Ca 통로 억제</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
142,865</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.42 </TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(10)Topiramate</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Na 통로 억제
GABA 수용체 활성화
Glutamate 억제</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
57,853</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1</TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(11)Pheytoin</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Na 통로 억제</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
10,531</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.19 </TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(12)Pregabalin</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Ca 통로 억제</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
9,086</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.44 </TD></TR>
<TR style="mso-yfti-irow: 15; mso-yfti-lastrow: yes">
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(13)Primidone</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
뇌감각피질 마비</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
3,104</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.84 </TD></TR></TBODY></TABLE>
 
 
<TABLE style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; WIDTH: 466.1pt; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184" border=1 cellSpacing=0 cellPadding=0 width=621 table>
<TBODY>
<TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes">
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 466.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" width=621 colSpan=4>
13종 항경련제의  자살시도, 자살사망, 폭력사망 
 유발 정도 비교 평가</TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
 </TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
약리 작용 </TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
약물 복용자
15세 이상</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
6개월 간 
발생위험율</TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" width=177>
 </TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" width=180>
신경 전달 
억제 기전</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" width=142>
(2001-2006)
미국 15개주 </TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" width=123>
Hazard
Ratio (HR)</TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(1)Oxcarbazepine</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Na 통로 억제
Ca 통로 억제</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
8,579</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
2.12</TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(2)Tiagabine</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Na 통로 억제
GABA 수용체 활성화</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
5,497</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
2.40</TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(3)Lamotrigine</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Na 통로 억제
Glutamate 억제</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
22.256
 </TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.86</TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(4)Valproate</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
GABA 수용체 활성화</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
18,295</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.69
 </TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(5)Levetiracetam</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Ca 통로억제
GABA수용체 활성화</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
3,975</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.66</TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(6)Phenobarbital</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
뇌감각피질 마비</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
2,130</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
0.96 </TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(7)Zonisamide</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Na 통로 억제
Ca 통로 억제</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
3,528</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.37</TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(8)Carbamazepine</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Na 통로억제</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
9,859</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.19 </TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(9)Gabapentine</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Ca 통로 억제</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
142,865</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.42 </TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(10)Topiramate</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Na 통로 억제
GABA 수용체 활성화
Glutamate 억제</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
57,853</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1</TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(11)Pheytoin</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Na 통로 억제</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 106.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #d9d9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=142>
10,531</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 92.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=123>
1.19 </TD></TR>
<TR>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 133pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=177>
(12)Pregabalin</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180>
Ca </S