간염 환자의 피로를 제거해 주는 약 > 임상 응용 정보

간염 환자의 피로를 제거해 주는 약

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 간염 환자의 피로를 제거해 주는 약 <?xml:namespace prefix = "o" ns = "urn:schemas-microsoft-com:office:office" /></TD></TR>
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간염 환자의 피로 증상을 제거 해 주는 약물이 
저명한 위장 계 전문 지(Gut) 를 통해 발표되었다 
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진토 제 Ondansetron의 항 피로 효과  </TD></TR>
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C형 바이러스 감염 등 간염 환자의 만성적 피로 증상에 
진토제 Ondansetron 이 잘 듣는다 
 
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Ondansetron 1일 2회 1회 4mg 경구 복용</TD></TR>
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피로 감소 정도</TD>
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약물 복용 기간</TD>
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치료 후</TD></TR>
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15일 째</TD>
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30일 째</TD>
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60일 째</TD></TR>
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Ondansetronn
투여군</TD>
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32.2%</TD>
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37.8%</TD>
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31.5%</TD></TR>
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Placebo
투여군</TD>
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13.6%</TD>
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20.4%</TD>
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5.7%</TD></TR>
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증상 진단 기준 :Fatigue Impact Scale questionnaire</TD></TR></TBODY></TABLE>
 
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우울 증상도 현저히 제거</TD></TR>
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간염 환자에게 피로 증상과 함께 합병되어 있는
우울 증상도 현저히 제거해 준다
 
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Ondansetron 1일 2회 1회 4mg 경구 복용</TD></TR>
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우울증 제거 정도</TD>
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약물 복용 기간</TD>
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치료 후</TD></TR>
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 </TD>
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15일 째</TD>
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30일 때</TD>
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60일째</TD></TR>
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Ondansetron
투여 군 </TD>
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37.3%</TD>
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35.0%</TD>
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41.9%</TD></TR>
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Placebo 
투여군 </TD>
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17.3%</TD>
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20.4%</TD>
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5.8%</TD></TR>
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증상 진단 기준 :the Beck Depression Inventory (BDI)</TD></TR></TBODY></TABLE>

 </TD></TR></TBODY></TABLE>
 
 
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만성 피로 증후군도 치료</TD></TR>
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진토제 Ondansetron 은 원인 불명의 질환인  
만성 피로증후군(Chronic Fatigue Syndrome) 에 대해서도
치료 효과 있음이 종종 발표되어 왔다
 
이러한 발표를 근거로 하여 Ondansetron 이
간염자의 피로 증후군에 대해서도
효과 있을 것이라는 가정 하에 
이중 맹검법에 의한 비교 임상 실시 결과 확인된 것이다
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피로에 효과를 발휘하는 이유</TD></TR>
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뇌의 중추에는  쾌락과 피로를 조절해 주는 
Hippocampus 라는 중추가 있다
 
간염 환자나  만성 피로 증후군 환자는
바로 이 중추의 신경 전달 수용체 (Serotonin 5-HT3)가
과잉으로 작동하는 자들이다
 
Ondansetron 은 바로 이 수용체를 과잉으로 작동 못 하도록 하는 
수용체 길항제 (Receptor Antagonist)다
 
 
구토를 유발하는  뇌의 신경 전달 수용체도 Serotonin 5-HT3 이므로
Ondabsetron 은 진토제로 사용되어 왔음은 주지의 사실이다
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근거</TD>
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Gut. 2005 Aug;54(8):1169-1173.           
Effect of ondansetron, a 5-HT3 receptor antagonist, 
on fatigue in chronic hepatitis C: a randomised, double blind, placebo controlled study. Piche T et al ; HepatoGastroenterologie, Hopital Archet 2, 
BP 3079, 06202 Nice cedex 3, France. 
 
May God bless you!
전성수</TD></TR></TBODY></TABLE>