파킨슨 병 증상 개선에 현저한 효과를 나타내는 비타민 D 의 작용 원리 > 임상 응용 정보

파킨슨 병 증상 개선에 현저한 효과를 나타내는 비타민 D 의 작용 원리

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파킨슨 병 증상 개선에 현저한 효과를 나타내는 
비타민 D 의 작용 원리   
 
 
 
<IMG style="WIDTH: 564px; HEIGHT: 611px" src="/_dimg/4-1%2020150324_123427.png" width=561 height=288> 
 
파킨슨 씨 병의 모든 증상에 비타민 D 가 현저한 효과를 
나타낸다는 사실이 이중 맹검 비교 임상을 통해 밝혀 졌다
 
이는 일본 도쿄 지게이 의대 연구 팀의 연구 결과이며
미국 임상 영양 학 전문지 를 통해 발표된 내용이다
 
 
 
비타민 D3 1일 1,200IU 1년간 복용으로 
18개 증상 판별 항목 중 12개 항목에 현저한 효과
 
파킨슨 병은 신경 전달 물질인 Dopamine 이 감소하므로 인해
 
동작장애
감정장애
인지 장애
행동 장애
사고 장애
감각 장애
수면장애 등이 계속 악화되기만 하는 병이다
 
따라서 파킨슨 병을 치료하는 약물은 현재의 증상을 
더 악화 되지 않게 하거나 
증상 정도를 완화 시키는 약들이다
 
본 이중 맹검 비교 임상에서는 
증상 정도 나 기타 병태가 유사한 파킨슨 병 환자를 
두 그릅으로 나누고
두릅 모두에게 L-dopa 요법은 수행한  하면서
 
비타민 D 1일 1,200IU투여 군과 Placebo 투여 군을 
12 개월간 비교한 결과 비타민 D 투여 군이 Placebo 투여군 보다 현저한 효과를 나타내었다
 
아래 표에서 처럼 18 개 조사 항목 중
12 항목에서 악화를 억제하거나 증상을 개선했다
 
 
 
<TABLE style="BORDER-COLLAPSE: collapse; mso-table-layout-alt: fixed; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" Table border=0 cellSpacing=0 cellPadding=0>
<TBODY>
<TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes">
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: windowtext 1pt solid; BORDER-RIGHT: windowtext 1pt solid; " width=121>
 </TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 9cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: windowtext 1pt solid; BORDER-RIGHT: windowtext 1pt solid; " width=340 colSpan=3>
증상 악화 억제 or 개선 자 %</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
판별 항목 </TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
Vitamin D
1일 1,200IU</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
Placebo</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
차이 (RR)
 </TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230" width=121>
 </TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230" width=132>
55 명</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230" width=113>
57명</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230" width=94>
 </TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
HY stage</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
29.1%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
12.3%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
2.37</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
UPDRS -total</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
38.2%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
38.6%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
0.99</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
UPDRS -1</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
21.8%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
21.1%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
1.04</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
UPDRS-2l</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
47.3%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
28.1%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
1.68</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
UPDRS -3</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
49.1%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
47.4%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
1.04</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
UPDRS -4</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
16.4%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
14.0%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
1.17</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
MMSI</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
63.3%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
78.2%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
0.81</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
PDQ39total </TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
67.3%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
56.4%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
1.19</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
PDQ39 병태</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
50.0%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
43.6%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
1.15</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
PDQ39일상생활</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
59.2%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
38.2%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
1,55</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
PDQ39감정상태</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
63.3%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
43.6%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
1.45</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
PDQ39수치동작</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
36.7%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
41.8%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
0.88</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
PDQ39대화</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
43.8%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
38.20%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
1.15.</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 90.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=121>
PDQ39도우미</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
60.4%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
41.8%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
1.44</TD></TR>
<TR >
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PDQ39사회생활</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=132>
27.1%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
21.8%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
1.24</TD></TR>
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PDQ39인지장애</TD>
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37.5%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
45.5%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
0.83</TD></TR>
<TR >
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EQ5D</TD>
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25.0%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
32.7%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
0.76</TD></TR>
<TR style="mso-yfti-irow: 20; mso-yfti-lastrow: yes">
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Visual analog</TD>
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52.`1%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=113>
61.8%</TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff99; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; " width=94>
0.84</TD></TR></TBODY></TABLE>
 
 
 
 
비타민 D 의 작용 원리 
 
뇌의 정신 기능과 신경기능 요소 요소에는 는 
비타민 D 수용체가 매우 많이 존재한다
 
특히 파킨슨병을 유발하는 곳인
뇌의 흑질(Substancia nigra)에는 비타민 D 수용체가 존재한다
 
파킨슨 병 환자는 이 같은 비타민 수용체를 생성시키는 
유전자가 변질 된 유전자(FokI TT or CT) 를 지닌 자들이 많다 
따라서 이들은 비타민 D 결핍 자가 많다
 
비타민 D 는  속성 동작을 발휘하는 
Type-2 근 섬유 비율을 증가시켜 순간 동작을 유지시켜 준다
 
Phosphocreatine 을 통해 ATP를 재생시켜 근력 을 증강시킨다
 
뼈의 재생을 유지시켜 골다공증 과 낙상을 예방한다
 
이러한 비타민 D 의 작용이 
파킨슨  병의 동작 병태를 개선 시킬 수 있다는 것은
예측 되는 일이다 
 
본 임상에서 비타민 D 를 하루 1,200iu 복용한 군은
임상 시작 시의 혈중 농도가 12개월 후에는 
정상 수준인 30ng/mL 보다 더 높은 41.7ng/mL 에
도달되어 있음을 보여준다
 
 
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 </TD>
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25(OH)D 혈중 농도</TD></TR>
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 </TD>
<TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 120.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230" width=161>
임상시작 시</TD>
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12개 월 후</TD></TR>
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비타민 투여군</TD>
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22.5ng/mL</TD>
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41.7ng/mL</TD></TR>
<TR style="mso-yfti-irow: 3; mso-yfti-lastrow: yes">
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Placebo 군</TD>
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21.1ng/mL</TD>
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21.4ng.mL</TD></TR></TBODY></TABLE>
 
 
 [근거]
AJCN. First published ahead of print March 13, 2013
Randomized, double-blind, placebo-controlled trial of vitamin D
supplement in Parkinson’s disease; Masahiko Suzuki, et al¨;
Department of Neurology, Katsushika Medical Center; Division of Molecular Epidemiology  Jikei University School of Medicine, Tokyo, Japan