Testosterone 효과가 나타나는 자의 특징과 효과없는 자의 특징 > 임상 응용 정보

Testosterone 효과가 나타나는 자의 특징과 효과없는 자의 특징

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Testosterone 효과가 나타나는 자의 특징 과 효과 없는 자의 특징
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효과 빈도</td>
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Testosterone 을 사용하는 자 중 2% 의 남성들에게만 
 
약효가 나타난다.
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무효 이유</td>
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발기 불능 이나 새벽 발기 불능 또는 성충동 등 대부분의 경우 
 
Testosterone이 모자라기 때문에 발생하는 경우가 아니기 때문이다.
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효과 대상</td>
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- 나이 들면서 Testosterone 분비 능력이 사라져가는 이른바 
 
  ‘남성호르몬 분비 저하증’(Hypogonadism)은 매우 소수의 사람들에게만 나타나며
 
  이러한 자들에게만 효과가 있다.
 
- Testostosrterone 의 혈중 농도가 11 nmol/L 이하인 자에게만 효과 있다.
 
- 성기능 장애 중 발기 불능과 새벽 발기 불능과 성충동 결여 라는 3대 성적 증상이
 
  동시에 나타나는 자에게 효과가 있다.
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임상실험 결과
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나이 별 효과</td>
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남성 호르몬 약효를 볼 수 있는 자는40대에서는 불과 0.1%이고 70대를 넘어선 
 
노인들도 불과 5%만이 약효를 볼 수 있었다.
 
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<v:shapetype id="_x0000_t75" o:spt="75" coordsize="21600,21600" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f"><v:stroke joinstyle="miter"></v:stroke><v:formulas><v:f eqn="if lineDrawn pixelLineWidth 0"></v:f><v:f eqn="sum @0 1 0"></v:f><v:f eqn="sum 0 0 @1"></v:f><v:f eqn="prod @2 1 2"></v:f><v:f eqn="prod @3 21600 pixelWidth"></v:f><v:f eqn="prod @3 21600 pixelHeight"></v:f><v:f eqn="sum @0 0 1"></v:f><v:f eqn="prod @6 1 2"></v:f><v:f eqn="prod @7 21600 pixelWidth"></v:f><v:f eqn="sum @8 21600 0"></v:f><v:f eqn="prod @7 21600 pixelHeight"></v:f><v:f eqn="sum @10 21600 0"></v:f></v:formulas><v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect"></v:path><o:lock v:ext="edit" aspectratio="t"></o:lock></v:shapetype><img src="/_dimg/1.png"></td></tr></tbody></table>
 
 나이 별 남성호르몬 분비 저하증 빈도: Testosteron 효과 볼수 있는 자
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발기 불능 자</td>
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발기가 불가능한 자나 정상적인 자나 혈중 Testosterone 농도는 차이가 거의 없다.
 
<img src="/_dimg/testosterone%201.jpg">
 
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(발기 불능:Erectile dysfunction)자(적색선)와 정상인(청색선)의 호르몬 농도
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새벽 발기
안되는 자</td>
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새벽 발기가 안 되는 자(적색선)나 잘 되는 자(청색선)나 다같이 
 
혈중 Testosterone 농도가 거의 비슷하다.
 
 
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성 충동
없는 자</td>
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성 충동이 없는 자(적색선)와 성 충동이 정상적인 자(청색선)의 
 
혈중 Testosterone 총 농도는 거의 비슷하다.
 
 
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비만도 별
차이</td>
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비만도가 증가하면 이에 비례하여 성기능 장애도 증가한다.
 
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합병증</td>
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합병증 종류 수가 증가하면 이에 비례하여 성기능 장애도 증가한다.
 
 
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근거</td>
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2010 June 16 New England Journal of Medicine (10.1056/NEJMoa0911101) : 
 
‘Identification of Late-Onset Hypogonadism in Middle-Aged and Elderly Men’ :
 
Frederick C.W. Wu, M.D.,etc. for the EMAS Group : Research Unit, Developmental 
 
and Regenerative Biomedicine Research Group, University of Manchester, 
 
Manchester Academic Health Science Centre, Manchester Royal Infirmary,</td></tr></tbody></table>