항균 제 Clarithromycin 투약 중 항압 제 Calcium 차단 제 동시 복용하면 안 되는 이유 페이지 정보 전성수 0 짧은주소 × 짧은 글주소 복사 Note! 위 주소를 클릭 후, 복사(Ctrl+C)하여 사용하세요. 이전글다음글 목록 본문 <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><B><SPAN style="COLOR: red; FONT-SIZE: 16pt; ">항균 제<SPAN > Clarithromycin </SPAN>투약 중</SPAN></B><SPAN style=" " ><?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /></SPAN></P> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><B><SPAN style="COLOR: red; FONT-SIZE: 16pt; ">항압 제<SPAN > Calcium </SPAN>차단 제 동시 복용하면 안 되는 이유</SPAN></B><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style="FONT-SIZE: 12pt; ">항균 제<SPAN > Clarithromycin </SPAN>투약 중 항압 제<SPAN > Calcium </SPAN>차단 제를</SPAN><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style="FONT-SIZE: 12pt; ">동시 복용하면 안 되는 이유가 밝혀 졌다</SPAN><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style="FONT-SIZE: 12pt; ">이는 캐나다<SPAN > Toronto </SPAN>의대 와<SPAN > Western </SPAN>의대 연구 팀의 연구 결과이며</SPAN><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style="FONT-SIZE: 12pt; ">미국 의사 회 학술 지 를 통해 발표된 내용이다</SPAN><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><B><SPAN style="COLOR: #0000cc; FONT-SIZE: 16pt; ">두 약을 병용하면<SPAN > 30</SPAN>일 내에</SPAN></B><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><B><SPAN style="COLOR: #0000cc; FONT-SIZE: 16pt; ">급성 신장 염을 일으키고 </SPAN></B><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><B><SPAN style="COLOR: #0000cc; FONT-SIZE: 16pt; ">모든 병으로 인한 사망 율을 증가시킨다</SPAN></B><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style="FONT-SIZE: 12pt; " >2003</SPAN><SPAN style="FONT-SIZE: 12pt; ">년부터<SPAN > 2012</SPAN>년 사이에<SPAN > Clarithromycin</SPAN>을 처방 받은 자 중</SPAN><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style="FONT-SIZE: 12pt; " >65</SPAN><SPAN style="FONT-SIZE: 12pt; ">세 이상인<SPAN > 96,226</SPAN>명을 대상으로 분석한 결과는 아래 표와 같다</SPAN><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style="FONT-SIZE: 12pt; ">칼슘 차단제를 복용한 자들은 칼슘 차단 제를 복용 안 한 사람에 대비하여</SPAN><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style="FONT-SIZE: 12pt; ">급성 신장 염 발생 위험율이<SPAN > 2.03 </SPAN>배<SPAN >dl</SPAN>며 저 혈압 발생 빈도는<SPAN > 1,63</SPAN>배 이고 </SPAN><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style="FONT-SIZE: 12pt; ">모든 병으로 부터의 사망률이<SPAN > 1.74</SPAN>배로 나타났다</SPAN><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <TABLE style="MARGIN: auto auto auto 19.6pt; BORDER-COLLAPSE: collapse; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" Table border=0 cellSpacing=0 cellPadding=0> <TBODY> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; " rowSpan=2 width=113> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " ><FONT size=2> </FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; " rowSpan=2 width=113> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2> </FONT></SPAN></P> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>Clarithromycin</FONT></SPAN></P> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >96,226 </SPAN><SPAN style=" ">명<SPAN ></SPAN></SPAN></FONT></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; " rowSpan=2 width=113> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2> </FONT></SPAN></P> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>Azithromycin</FONT></SPAN></P> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >94,083</SPAN><SPAN style=" ">명<SPAN ></SPAN></SPAN></FONT></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 127.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; " width=170 colSpan=2> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >Macrolide</SPAN><SPAN style=" ">계<SPAN ></SPAN></SPAN></FONT></P></TD></TR> <TR > <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=76> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" "><FONT size=2>절대<SPAN ></SPAN></FONT></SPAN></P> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" "><FONT size=2>발생<SPAN > %</SPAN></FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" "><FONT size=2>비교 발생<SPAN ></SPAN></FONT></SPAN></P> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" "><FONT size=2>위험율<SPAN >(OR)</SPAN></FONT></SPAN></P></TD></TR> <TR > <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=113> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" "><FONT size=2>급성 신부전 <SPAN ></SPAN></FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=113> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0..44%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=113> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.22%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=76> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.22%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >2.03</SPAN><SPAN style=" ">배<SPAN ></SPAN></SPAN></FONT></P></TD></TR> <TR > <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=113> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" "><FONT size=2>저 혈압<SPAN ></SPAN></FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=113> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.17%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=113> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.07%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=76> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.04%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >1.63</SPAN><SPAN style=" ">배<SPAN ></SPAN></SPAN></FONT></P></TD></TR> <TR style="mso-yfti-irow: 4; mso-yfti-lastrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=113> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" "><FONT size=2>모든 병의사망<SPAN ></SPAN></FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=113> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>1.02%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=113> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.59%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=76> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.43%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >1.74</SPAN><SPAN style=" ">배<SPAN ></SPAN></SPAN></FONT></P></TD></TR></TBODY></TABLE> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><B><SPAN style="COLOR: #0000cc; FONT-SIZE: 16pt; " >Clarithromycin </SPAN></B><B><SPAN style="COLOR: #0000cc; FONT-SIZE: 16pt; ">복용 자가 동시 복용하는</SPAN></B><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><B><SPAN style="COLOR: #0000cc; FONT-SIZE: 16pt; ">여러 자지 칼슘 차단 제 별 급성 신부전 발생 비교</SPAN></B><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <TABLE style="MARGIN: auto auto auto 19.6pt; WIDTH: 297.65pt; BORDER-COLLAPSE: collapse; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" Table border=0 cellSpacing=0 cellPadding=0 width=397> <TBODY> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; " width=94> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " ><FONT size=2> </FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 78pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; " width=104> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2> </FONT></SPAN></P> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>Clarithromycin</FONT></SPAN></P> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >96,226 </SPAN><SPAN style=" ">명<SPAN ></SPAN></SPAN></FONT></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; " width=94> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2> </FONT></SPAN></P> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>Azithromycin</FONT></SPAN></P> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >94,083</SPAN><SPAN style=" ">명<SPAN ></SPAN></SPAN></FONT></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; " width=104> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >Macrolide</SPAN><SPAN style=" ">계<SPAN ></SPAN></SPAN></FONT></P> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" "><FONT size=2>비교 발생 <SPAN ></SPAN></FONT></SPAN></P> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" "><FONT size=2>위험율<SPAN >(OR)</SPAN></FONT></SPAN></P></TD></TR> <TR > <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " ><FONT size=2>Nifedipine</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 78pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=104> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.78%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.15%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=104> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >5.33 </SPAN><SPAN style=" ">배<SPAN ></SPAN></SPAN></FONT></P></TD></TR> <TR > <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " ><FONT size=2>Felodipine</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 78pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=104> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.46%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.16%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=104> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >2.97 </SPAN><SPAN style=" ">배<SPAN ></SPAN></SPAN></FONT></P></TD></TR> <TR > <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " ><FONT size=2>Amlodipine</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 78pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=104> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.4%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.25</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=104> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >1.61 </SPAN><SPAN style=" ">배<SPAN ></SPAN></SPAN></FONT></P></TD></TR> <TR > <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " ><FONT size=2>Diltiazem</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 78pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=104> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.29%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.22%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=104> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >1.36 </SPAN><SPAN style=" ">배<SPAN ></SPAN></SPAN></FONT></P></TD></TR> <TR style="mso-yfti-irow: 5; mso-yfti-lastrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " ><FONT size=2>Verapmail</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 78pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=104> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.24%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.24%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=104> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >0.97 </SPAN><SPAN style=" ">배<SPAN ></SPAN></SPAN></FONT></P></TD></TR></TBODY></TABLE> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><B><SPAN style="COLOR: #0000cc; FONT-SIZE: 16pt; " >Clarithromycin </SPAN></B><B><SPAN style="COLOR: #0000cc; FONT-SIZE: 16pt; ">과 칼슘 차단제 동시 복용의 부작용은 </SPAN></B><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><B><SPAN style="COLOR: #0000cc; FONT-SIZE: 16pt; ">주로 복용 후<SPAN > 30</SPAN>일 이내 발생 했다</SPAN></B><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <TABLE style="MARGIN: auto auto auto 40.85pt; BORDER-COLLAPSE: collapse; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 0cm 0cm 0cm; " Table border=0 cellSpacing=0 cellPadding=0> <TBODY> <TR style="HEIGHT: 25.35pt; mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 86.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; HEIGHT: 25.35pt; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; " width=116> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " ><FONT size=2> </FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 125.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; HEIGHT: 25.35pt; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; " width=168 colSpan=2> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>Clarithromycin</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 127.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; HEIGHT: 25.35pt; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; " width=170 colSpan=2> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" "><FONT size=2>발생 위험율<SPAN > (OR)</SPAN></FONT></SPAN></P></TD></TR> <TR > <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 86.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" width=116> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " ><FONT size=2> </FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 69.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" width=92> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" "><FONT size=2>급성 싱부전<SPAN ></SPAN></FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" width=76> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" "><FONT size=2>저혈압<SPAN ></SPAN></FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" width=94> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" "><FONT size=2>급성 신부전<SPAN ></SPAN></FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" width=76> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style="FONT-SIZE: 12pt; ">저혈압</SPAN><SPAN style=" " ></SPAN></P></TD></TR> <TR > <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 86.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=116> <P style="MARGIN: 0cm 0cm 0pt; " align=left><FONT size=2><SPAN style=" " >30</SPAN><SPAN style=" ">일 이내 발생<SPAN ></SPAN></SPAN></FONT></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 69.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=92> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.17%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=76> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.05%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >2.92</SPAN><SPAN style=" ">배<SPAN ></SPAN></SPAN></FONT></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=76> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style="FONT-SIZE: 12pt; " >3.57</SPAN><SPAN style="FONT-SIZE: 12pt; ">배</SPAN><SPAN style=" " ></SPAN></P></TD></TR> <TR > <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 86.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=116> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" "><FONT size=2>병용전신<SPAN >90</SPAN>일간 <SPAN ></SPAN></FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 69.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=92> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.04%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=76> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.01%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >1.04</SPAN><SPAN style=" ">배<SPAN ></SPAN></SPAN></FONT></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=76> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style="FONT-SIZE: 12pt; " >3.46</SPAN><SPAN style="FONT-SIZE: 12pt; ">배</SPAN><SPAN style=" " ></SPAN></P></TD></TR> <TR style="mso-yfti-irow: 4; mso-yfti-lastrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 86.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=116> <P style="MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" "><FONT size=2>병용후<SPAN > 9-</SPAN>일째<SPAN ></SPAN></FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 69.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=92> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.06%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=76> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style=" " ><FONT size=2>0.04%</FONT></SPAN></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=94> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><FONT size=2><SPAN style=" " >0.87</SPAN><SPAN style=" ">배<SPAN ></SPAN></SPAN></FONT></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; " width=76> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt; " align=center><SPAN style="FONT-SIZE: 12pt; " >1.33</SPAN><SPAN style="FONT-SIZE: 12pt; ">배</SPAN><SPAN style=" " ></SPAN></P></TD></TR></TBODY></TABLE> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 16pt; MARGIN: 0cm 0cm 0pt; " align=left><B><SPAN style="COLOR: #0000cc; FONT-SIZE: 16pt; ">상호 작용에 의한 부작용 발생 원리</SPAN></B><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style="FONT-SIZE: 12pt; ">항압 제 칼슘 차단 제는 간에서 특정 효소에 의해 활성 화 되거나 </SPAN><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style="FONT-SIZE: 12pt; ">사용된 후 특정 효소에 의해 간에서 분해 되어 배설 된다 </SPAN><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style="FONT-SIZE: 12pt; ">이처럼 약물을 변화 시키는 약물 대사 효소는 무려<SPAN > 500</SPAN>이종아 밝혀저 있으며</SPAN><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style="FONT-SIZE: 12pt; ">약물의 분자 굳조에 따라 효소의 종류들이 다르다 </SPAN><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style="FONT-SIZE: 12pt; ">특히 칼슘 차단 제를 변화시키는 효소인<SPAN > Cy3A3</SPAN>은<SPAN > Macrolide </SPAN>계 항생제에 의해 억제되지만 특히<SPAN > Nifedipine, Felodipine, Amlodipine </SPAN>순으로 억제된다</SPAN><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt; " align=left><SPAN style=" " > </SPAN></P> <P style="MARGIN: 0cm 0cm 0pt 12pt; " align=left><SPAN style="FONT-SIZE: 12pt; ">에를 들어<SPAN > Amlodipine</SPAN>이 효소<SPAN > Cyp3/4 </SPAN>에 억제되면 </SPAN><SPAN style=" " ></SPAN></P> <P style="MARGIN: 0cm 0cm 0pt 12pt; " align=left><SPAN style="FONT-SIZE: 12pt; " >Amlodipine</SPAN><SPAN style="FONT-SIZE: 12pt; ">의 혈중 농도가 증가며 따라서 저혈압이 발생 한다</SPAN><SPAN style=" " ></SPAN></P> <P style="MARGIN: 0cm 0cm 0pt 12pt; " align=left><SPAN style=" " > </SPAN></P> <P style="MARGIN: 0cm 0cm 0pt 12pt; " align=left><SPAN style="FONT-SIZE: 12pt; ">또한 저혈압으로인해 사구 체 여과 율이 감소하여 급성 신장 염을 일으킨다</SPAN><SPAN style=" " ></SPAN></P> <P style="MARGIN: 0cm 0cm 0pt 12pt; " align=left><SPAN style=" " > </SPAN></P> <P style="MARGIN: 0cm 0cm 0pt 12pt; " align=left><SPAN style=" " > </SPAN></P> <P style="MARGIN: 0cm 0cm 0pt 12pt; " align=left><SPAN style="FONT-SIZE: 12pt; " >[</SPAN><SPAN style="FONT-SIZE: 12pt; ">근거<SPAN >]</SPAN></SPAN><SPAN style=" " ></SPAN></P> <P style="MARGIN: 0cm 0cm 0pt 12pt; " align=left><B><SPAN style="FONT-SIZE: 12pt; " >JAMA. Published online November 09, 2013</SPAN></B><SPAN style=" " ></SPAN></P> <P style="MARGIN: 0cm 0cm 0pt 12pt; " align=left><B><SPAN style="FONT-SIZE: 12pt; " >Calcium-Channel Blocker</SPAN></B><B><SPAN style="FONT-SIZE: 12pt; ">–<SPAN >Clarithromycin Drug Interactions and Acute Kidney Injury F; Sonja Gandhi, BSc1,2; Jamie L. Fleet, BHSc1; David G. Bailey, BScPhm, PhD3; Eric McArthur, MSc1,4; Ron Wald, MD5; Faisal Rehman, MD1; Amit X. Garg, MD, PhD1,2,3,4 </SPAN></SPAN></B><SPAN style=" " ></SPAN></P> <P style="TEXT-INDENT: 6pt; MARGIN: 0cm 0cm 0pt 6pt; mso-para-margin-left: .6gd" align=left><B><SPAN style="FONT-SIZE: 12pt; " >Division of Nephrology, Department of Medicine, Western University, London, Canada Department of Epidemiology and Biostatistics, Western University, London, Canada 3Lawson Health Research Institute, London Health Sciences Centre, London, Canada Institute for Clinical Evaluative Sciences, Ontario, Canada Division of Nephrology, Department of Medicine, St Michael</SPAN></B><B><SPAN style="FONT-SIZE: 12pt; ">’<SPAN >s Hospital and University of Toronto, Toronto, Canada </SPAN></SPAN></B><SPAN style=" " ></SPAN></P> <P style="MARGIN: 0cm 0cm 0pt"><SPAN ><FONT size=3 face=굴림> </FONT></SPAN></P> 이전글다음글 목록
