향 정신병 약물 복용하면 비만 해지는 이유 와 대처 방법 페이지 정보 전성수 0 짧은주소 × 짧은 글주소 복사 Note! 위 주소를 클릭 후, 복사(Ctrl+C)하여 사용하세요. 이전글다음글 목록 본문 <TABLE style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" border=1 cellSpacing=0 cellPadding=0 width=790> <TBODY> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: aqua; VERTICAL-ALIGN: middle; BORDER-TOP: windowtext 1pt solid; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" width=790 colSpan=3> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 24pt">향 정신병 약물 복용하면 </SPAN></B><SPAN style="COLOR: black; FONT-SIZE: 24pt"></SPAN></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 24pt"></SPAN></B> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 24pt"> </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 24pt">비만 해지는 이유 와 대처 방법</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fabf8f; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid" width=20> <P style="MARGIN: 0cm 0cm 0pt"> </P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: #fde9d9; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" width=770 colSpan=2> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Clozapine, Olanzapine, Quetiapine </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">같은 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">정신병 약을 복용하면 몸이 비대 해 진다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">비만 성 당뇨 병이 나타나고 <SPAN><BR></SPAN>심장병 등 합병증이 발생한다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">지금 까지는 그 이유가 해명되지 못했으므로 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">몸이 비대 해 지면 처방을 바꾸는 수 밖에 없었다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이제 그 이유가 존 홉킨스 의대 연구 팀에 의해 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">명백하게 밝혀졌으며 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">첨단 과학 아카데미 학술지<SPAN>(PNAS)</SPAN>를 통해 </SPAN></B><SPAN style="COLOR: black; FONT-SIZE: 14pt">발표<B> 되었다 </B></SPAN></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">아울러 대책을 강구 할 수 있게 되었다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="FONT-SIZE: 14pt"><IMG src="/_dimg/1%20비만.bmp"></SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: aqua; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=3> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt">시상 하부 식욕 중추를 자극</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fabf8f; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid" width=20> <P style="MARGIN: 0cm 0cm 0pt"> </P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: #fde9d9; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=2> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Clozapine, Olanzapine</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">같은 이른바 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">비정형 향 정신병 약<SPAN>(AAPD)</SPAN>은 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">뇌의<SPAN> Serotonin </SPAN>수용체나 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">도파 민 수용체에 작용하는 약들이다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">그러나 시상 하부 식욕 중추에 있는 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Histaine-1 </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">수용체도 자극하여</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">AMPK </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">라는 효소를 활성화 시킨다는 사실이 발견되었다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">식욕 중추의 효소<SPAN> (AMPK)</SPAN>가 활성화 되면<SPAN><SPAN> </SPAN></SPAN></SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">식욕이 촉진 되어 계속 먹게 되고 비대해 진다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"></SPAN></B> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"><IMG src="/_dimg/2%20clozap.bmp"></SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">[</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">그림<SPAN>] Clozapine </SPAN>은 식욕 중추의<SPAN><SPAN> </SPAN></SPAN></SPAN></B></P> <P style="TEXT-INDENT: 42pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">H1(Histamine -1) </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">수용체에도 작용 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"><IMG src="/_dimg/3%20ampk.bmp"></SPAN></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt">[</SPAN><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">그림<SPAN>] Clozapine </SPAN>이 시상하부에서<SPAN>AMPK</SPAN>를 활성화 시킴</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"></SPAN></B> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"></SPAN></B> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"></SPAN></B> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"></SPAN></B> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"><IMG src="/_dimg/4%20%20시상하부.bmp"></SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">[</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">그림<SPAN>] </SPAN>시사하부<SPAN>(Hypothalamus) </SPAN>이 식욕중추에서 효소<SPAN> AMPK</SPAN>가</SPAN></B></P> <P style="TEXT-INDENT: 42pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">활성화 되면 식욕이 증가하여 비만화 된다</SPAN></B></P> <P style="TEXT-INDENT: 42pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"></SPAN></B> </P> <P style="TEXT-INDENT: 42pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"></SPAN></B> </P> <P style="TEXT-INDENT: 42pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"></SPAN></B> </P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: aqua; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=3> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt">대사 증후군으로 직결</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fabf8f; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid" width=20> <P style="MARGIN: 0cm 0cm 0pt"> </P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: #fde9d9; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=2> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">향 정신 약물로 인한 비대는 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">허리 부분이 비대 해 지는 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이른바 대사 증후군<SPAN>(Metabolic syndrome)</SPAN>으로 직결된다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">해서<SPAN> Insulin </SPAN>내성이 나타 나고 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">고 지혈 증이 나타나고 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">당뇨 병이 나타 나며 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">순환기 합병 증이 나타난다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"><IMG src="/_dimg/5%20.대사증후.bmp"></SPAN></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">[</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">그림<SPAN>] </SPAN>비만은<SPAN> Insulin </SPAN>내성을 유발시켜 당뇨병을 발생시킴 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: aqua; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=3> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="FONT-FAMILY: '새굴림','serif'; COLOR: blue; FONT-SIZE: 24pt">체중을 감소 시키는 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><SPAN style="FONT-FAMILY: 굴림; COLOR: black; FONT-SIZE: 12pt"> </SPAN><B><SPAN style="FONT-FAMILY: '새굴림','serif'; COLOR: blue; FONT-SIZE: 24pt">당뇨병 약<SPAN> </SPAN></SPAN></B><B><SPAN style="FONT-FAMILY: 굴림; COLOR: blue; FONT-SIZE: 24pt"> Metformin</SPAN></B></P></TD></TR> <TR style="HEIGHT: 467.5pt; mso-yfti-irow: 7; mso-yfti-lastrow: yes"> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fabf8f; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid" width=20> <P style="MARGIN: 0cm 0cm 0pt"> </P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: #fde9d9; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=2> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">당뇨병 약<SPAN> Metformin </SPAN>의 약효의 본질은</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> AMPK</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">라는 효소를 활성화 시키는 데 잇다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">AMPK</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">를 활성 화 시켜 혈당을 내린다 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">지질을 감소시키고 체중을 감소 시킨다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">그러나 </SPAN></B><B><SPAN style="FONT-SIZE: 14pt">약리 의 모순은 없다<SPAN style="COLOR: blue"></SPAN></SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">항 정신 병 약은 시상하부의<SPAN> AMPK </SPAN>를 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">활성화 시켜 체중이 증가한다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Metformin</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">은 지방 조직과 간 과 근육에서 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"> <B>AMPK</B></SPAN><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">를 활성화 시켜 비만 체중을 정상화 한다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">AMPK </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">라는 효소는 그 종류가<SPAN> 6</SPAN>가지로 나누어지며</SPAN></B><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">효소가 존재하는 위치에 따라 작용이 반대로 나타날 수 있다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Metformin, </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">은 시상하부의<SPAN> AMPK</SPAN>에는 작용을 안하며</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">향 정신 약은 간이나 근육에 있는<SPAN> AMPK </SPAN>에는 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">작용을 안 하기 때문이다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Metformin </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">은 탄수화물과 지질 대사를 정상 화 시키는</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">AMPK </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">활성 화 제 이다 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><SPAN style="COLOR: black; FONT-SIZE: 14pt"></SPAN> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">따라서 향 정신 약물로 인한 비만 자에게 비만 치료제로</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">당뇨병 후보인 당 불 내성 환자에게</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">당뇨병 예방 약으로 사용 할 수 있다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left> </P> <TABLE style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" border=1 cellSpacing=0 cellPadding=0> <TBODY> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 443.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: windowtext 1pt solid; BORDER-RIGHT: windowtext 1pt solid" width=591 colSpan=2> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">대부분의 향 정신병약은 비만을 유발 하지만</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 221.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: windowtext 1pt solid" width=296> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">유발 율이 가장 많은 것</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 221.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: windowtext 1pt solid" width=296> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">유발 율이 낮은 것</SPAN></B></P></TD></TR> <TR style="mso-yfti-irow: 2; mso-yfti-lastrow: yes"> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 221.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ffffff; BORDER-RIGHT: windowtext 1pt solid" width=296> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Clozapine</SPAN></B></P> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Olanzapine</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 221.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ffffff; BORDER-RIGHT: windowtext 1pt solid" width=296> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Risperidone</SPAN></B></P> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Ziprasidone</SPAN></B></P></TD></TR></TBODY></TABLE></TD></TR> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes; mso-yfti-lastrow: yes"> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fabf8f; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid" width=20> <P style="MARGIN: 0cm 0cm 0pt"> </P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; BACKGROUND: #d9d9d9; VERTICAL-ALIGN: middle; BORDER-TOP: windowtext 1pt solid; BORDER-RIGHT: windowtext 1pt solid" width=80> <P style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><B><SPAN style="FONT-SIZE: 14pt">근거</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: #f2f2f2; VERTICAL-ALIGN: middle; BORDER-TOP: windowtext 1pt solid; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" width=690> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Proceedings of the National Academy of Sciences; 2007 Feb.20, vol. 104 no. 9<SPAN> </SPAN>3456-3459 Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase ;Kim et al.</SPAN></B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> <B>Department of Neuroscience, Departments of </B></SPAN></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0.75pt 0cm" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Pharmacology and Molecular Sciences and Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, </SPAN></B></P></TD></TR></TBODY></TABLE> 이전글다음글 목록
