비만을 억제해 주는 Ketotifen 항 알러지 약의 작용 원리 페이지 정보 전성수 0 짧은주소 × 짧은 글주소 복사 Note! 위 주소를 클릭 후, 복사(Ctrl+C)하여 사용하세요. 이전글다음글 목록 본문 <TABLE style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; WIDTH: 790px; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" border=1 cellSpacing=0 cellPadding=0> <TBODY> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; WIDTH: 790px; PADDING-RIGHT: 30px; BACKGROUND: aqua; VERTICAL-ALIGN: middle; BORDER-TOP: windowtext 1pt solid; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=3> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 24pt">비만을 억제해 주는<SPAN> Ketotifen </SPAN></SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 24pt"></SPAN></B> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 24pt">항 알러지 약의 작용 원리</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; WIDTH: 20px; BACKGROUND: #fabf8f; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <P style="MARGIN: 0cm 0cm 0pt"> </P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; WIDTH: 770px; PADDING-RIGHT: 30px; BACKGROUND: #fde9d9; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=2> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">천식에 사용되고 있는<SPAN> Ketotifen </SPAN>등의 항알러지 약이</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">체중을 감소 시키며 또 비만을 예방한다는 사실이 밝혀졌다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">뿐만 아니라 당뇨병 발생을 예방 할 수 있는 가능성도</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">확인 되었다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Ketotifen</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">은 알러지 유발 세포인 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">비만 세포<SPAN>(Mast Cell)</SPAN>의 작용을 억제하는 약이다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">비만 세포막에 결합함으로써 비만 세포막으로부터 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">알러지 유발 물질의 분비를 억제할 수 있기 때문이다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">놀랍게도 이러한 알러지 유발 세포인 비만 세포가 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">식이성 지방 살을 증가시키는 주역 세포임이 입증된 것이다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">아울러 <SPAN>Ketotifen </SPAN>은 비만 세포의 작용을 억제함으로써 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">비만을 억제한다는 사실이 함께 입증되었다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">본 연구를 통해 밝혀진 바에 의하면</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">비만 성 식사를 하는 경우</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">비만 세포가 복부에 집결하여 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">지방조직 증식에 필요한 신생 혈관을 생성시킨다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">해서 복부 비만이 형성된다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">또한 비만세포는 지방 대사를 억제하여 혈당을 상승시킨다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">따라서<SPAN> Ketotifen</SPAN>은 혈당도 내려준다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이 연구는 하버드의대 연구팀의 연구 결과이며</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Nature Medicine</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">지를 통해 발표된 것이다</SPAN></B> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"><SPAN><IMG src="/_dimg/1%20mast%20cell.bmp"></SPAN></SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">[</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">그림<SPAN>] </SPAN>앨러지를 일으키는 면역 세포로 알려저온 </SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt 50pt; mso-para-margin-left: 5.0gd" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">비만세포<SPAN>(Mast cell)</SPAN>는 전신에 작용하여 조직에 변화를 일으키고 염증을 일으키고 조직 기능을 변화 시킨다</SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">특히 비만을 일으키는 주역임이 밝혀지므로서 그</SPAN></B></P> <P style="TEXT-INDENT: 42pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">이름 값을 하고 있다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"></SPAN></B> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"><IMG src="/_dimg/2%20ketotifen.bmp"></SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">[</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">그림<SPAN>] </SPAN>항 앨러지 약 <SPAN>ketotifen: </SPAN>비만세포의 작용을 억제하여 </SPAN></B></P> <P style="TEXT-INDENT: 42pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">천식도 치료하지만 비만을 예방 치료하고 </SPAN></B></P> <P style="TEXT-INDENT: 42pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">전 당뇨병 환자의 혈당도 내려줄 수 있음이 입증되었다</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: aqua; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=3> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt">비만 조직 형성시키는 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 96pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 4.0" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt">비만세포<SPAN> (Mast Cell)</SPAN></SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; BACKGROUND: #fabf8f; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <P style="MARGIN: 0cm 0cm 0pt"> </P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: #fde9d9; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=2> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이미 비만인 자의 복부지방이나</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">비만 성 식사를 하는 자들의 복부 지방에는 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">비만 세포가 정상인 보다 집중적으로 집결된다<SPAN> (</SPAN>위 그림 참조<SPAN>)</SPAN></SPAN></B> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"><IMG src="/_dimg/3%20비만%20집결.bmp"> </SPAN></B></P> <P style="TEXT-INDENT: -56pt; MARGIN: 0cm 0cm 0pt -84pt; mso-para-margin-left: -14.0gd; mso-char-indent-count: -4.0" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">[[</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">그림<SPAN> 1] <SPAN> </SPAN>[</SPAN>그림<SPAN>] </SPAN>비만 세포가 복부 백색 지방<SPAN>(WAT)</SPAN>에 집결된다</SPAN></B></P> <P style="TEXT-INDENT: 97.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 6.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">비만도<SPAN> 32 </SPAN>이상인 비만 자<SPAN>(Obese)</SPAN>에게서는 </SPAN></B></P> <P style="TEXT-INDENT: 97.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 6.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">비만도<SPAN> 26 </SPAN>이하인 여윈 자<SPAN>(Lean)</SPAN>에게서 보다 </SPAN></B></P> <P style="TEXT-INDENT: 97.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 6.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">많은 비만 세포가 집결하고 있다.</SPAN></B></P> <P style="TEXT-INDENT: 182pt; MARGIN: 0cm 0cm 0pt -80.2pt; mso-para-margin-left: -8.02gd; mso-char-indent-count: 13.0" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">WAT (white adipose tissue): </SPAN></B></P> <P style="TEXT-INDENT: 182pt; MARGIN: 0cm 0cm 0pt -80.2pt; mso-para-margin-left: -8.02gd; mso-char-indent-count: 13.0" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">백색 지방은 지방을 저장만하는 지방세포이며<SPAN> </SPAN></SPAN></B></P> <P style="TEXT-INDENT: 97.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 6.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">비만 식을 지속하면 세포가 커지고 </SPAN></B></P> <P style="TEXT-INDENT: 97.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 6.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">그 수효가 많아지면서 비만화 된다.</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B></P> <P style="TEXT-INDENT: 97.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 6.98" align=left> </P> <P style="TEXT-INDENT: 97.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 6.98" align=left> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="FONT-SIZE: 14pt"><SPAN><IMG src="/_dimg/4%20ucp1.bmp"> </SPAN></SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">[</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">그림<SPAN>] </SPAN>비만 세포는 지방산을 산화시켜 열을 발생시키는 </SPAN></B></P> <P style="TEXT-INDENT: 56pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 4.0" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">유전자 <SPAN>(UCP-1) </SPAN>발현을 억제하여 </SPAN></B></P> <P style="TEXT-INDENT: 56pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 4.0" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">지방을 축적시켜 비만화 한다<SPAN>. </SPAN></SPAN></B></P> <P style="TEXT-INDENT: 56pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 4.0" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">항알러지 약은 이러한 비만세포의</SPAN></B></P> <P style="TEXT-INDENT: 55.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 3.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">작용을 억제하여 비만 식사 시 비만화를 예방한다.</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: aqua; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=3> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt">항알러지 약 <SPAN>Ketotifen </SPAN>은 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt"></SPAN></B> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt">비만 예방 효과를 발휘한다</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; BACKGROUND: #fabf8f; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <P style="MARGIN: 0cm 0cm 0pt"> </P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: #fde9d9; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" width=607 colSpan=2> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">비만 세포의 작용을 억제하는 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Ketotifen</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이나 <SPAN>Cromoglycate </SPAN>같은 항 알러지 약은</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">비만식을 하는 과정에서부터 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">비만 성 지방 조직 형성을 억제한다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"><IMG src="/_dimg/5%20체중감소.bmp"></SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">[</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">그림<SPAN>] </SPAN>항알러지 약을 투약한 쥐와 비만 세포 작용 없앤 쥐 및 </SPAN></B></P> <P style="TEXT-INDENT: 55.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 3.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">대조군으로서의 정상적 쥐를 대상으로 하여</SPAN></B></P> <P style="TEXT-INDENT: 55.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 3.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">비만 식 섭취 하에서 체중 증가 및 억제 작용을 비교<SPAN>,</SPAN></SPAN></B></P> <P style="TEXT-INDENT: 55.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 3.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">또한 비만 상태에서의 체중 감소 효과 비교</SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> </SPAN></B></P> <P style="TEXT-INDENT: 55.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 3.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">WT ------------------------ </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">정상 쥐<SPAN> (</SPAN>대조군<SPAN>)</SPAN></SPAN></B></P> <P style="TEXT-INDENT: 55.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 3.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">WT + DSCG------------------</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">항앨러지약 투여</SPAN></B></P> <P style="TEXT-INDENT: 55.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 3.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">Kit <SUP>W-shW-sh</SUP> ------------------</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">비만세포 작용 없앤 쥐 </SPAN></B></P> <P style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt 39.8pt; mso-para-margin-left: 3.98gd" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">Kit <SUP>W-shW-sh</SUP><SPAN> </SPAN>+ DSCG-</SPAN></B></P> <P style="TEXT-INDENT: 42pt; MARGIN: 0cm 0cm 0pt 39.8pt; mso-para-margin-left: 3.98gd" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">------- </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">비만세포 작용 없앤 쥐<SPAN> + Cromoglycate</SPAN></SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: aqua; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=3> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt">체중 감소 효과를 발휘한다</SPAN></B></P></TD></TR> <TR style="HEIGHT: 311.4pt; mso-yfti-irow: 7"> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; BACKGROUND: #fabf8f; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid" width=15> <P style="MARGIN: 0cm 0cm 0pt"> </P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: #fde9d9; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" width=607 colSpan=2> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">천식 약인 <SPAN>Ketotifen</SPAN>이나 <SPAN>Cromoglycate</SPAN>은 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">비만 식을 하는 동안 지방 살이 찌지 않게 하는 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">예방 효과를 발휘 할 뿐 아니라</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이미 비만화 된 지방 살도 감소시켜</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">체중을<SPAN> 8</SPAN>주 이내에 <SPAN>19%</SPAN>나 감소시킨다 <SPAN>(</SPAN>위 그림 참조<SPAN>)</SPAN></SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"><IMG src="/_dimg/6%20체주%20ㅇ감소.bmp"> </SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">[</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">그림<SPAN>] </SPAN>항 앨러지 약은 체중 감소 및 혈당을 강하시킨다</SPAN></B></P> <P style="TEXT-INDENT: 55.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 3.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">쥐에게<SPAN> 12</SPAN>주간 비만 식 투여하여 비만 및 </SPAN></B></P> <P style="TEXT-INDENT: 55.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 3.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">당뇨병 유발시킨 뒤</SPAN></B></P> <P style="TEXT-INDENT: 55.7pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 3.98" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">아래와 같이 <SPAN>4</SPAN>군으로 나누어 비교 한 결과<SPAN>:</SPAN></SPAN></B></P> <P style="TEXT-INDENT: 69.6pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 4.97" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">Group 1---</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">비만 식만 계속 투여</SPAN></B></P> <P style="TEXT-INDENT: 69.6pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 4.97" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">Group 2-- </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">비만 식 투여하다가 지질 저 하식 투여하면</SPAN></B></P> <P style="TEXT-INDENT: 165.6pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 11.83" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">---> </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">체중<SPAN> 8% </SPAN>저하 및 혈당도 개선</SPAN></B></P> <P style="TEXT-INDENT: 69.6pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 4.97" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">Group 3-- </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">비만 식 계속하면서 항알러지약 투약하면</SPAN></B></P> <P style="TEXT-INDENT: 110.9pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 7.92" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"><SPAN> </SPAN>---> 3</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">주 투여 후 체중<SPAN> 12% </SPAN>감소</SPAN></B></P> <P style="TEXT-INDENT: 69.6pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 4.97" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">Group 4---</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">지질 저하식으로 전환 후 항알러지약 투여하면</SPAN></B></P> <P style="TEXT-INDENT: 97.15pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 6.94" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> <SPAN> </SPAN>---> 3</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">주 투여 후 체중<SPAN> 19% </SPAN>감소<SPAN>, </SPAN></SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 140pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">체중<SPAN> 40-41 </SPAN>그램으로 안정 화됨</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: aqua; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=3> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt">혈관 생성을 억제하여</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt"></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 24pt"></SPAN></B> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt"> </SPAN></B><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt">복부 비만을 억제한다</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; BACKGROUND: #fabf8f; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid" width=15> <P style="MARGIN: 0cm 0cm 0pt"> </P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: #fde9d9; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" width=607 colSpan=2> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> 알러지 유발 세포인 비만세포는 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">우리가 비만 식을 하는 경우 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">지방 조직 혈관 주위에 집결되어</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Cathepsin</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이라는 물질을 활성화 시킨다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이 물질이 지방 조직 사이 사이에 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">신생 혈관을 자라나게 하여 지방 살을 찌게 한다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">항알러지 약은 비만 세포의 작용을 억제하므로</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Cathepsin</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">의 활성화를 억제하여 복부 비만을 방지한다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"><IMG src="/_dimg/7%20cathepsi.bmp"></SPAN></B></P> <P style="TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">[</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">그림<SPAN>] </SPAN>비만세포가 분비하는<SPAN> cytokine IL-6 </SPAN>와<SPAN> INF-</SPAN>γ가 </SPAN></B></P> <P style="TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> Cathepsin</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">을 활성화시켜 비만조직을 형성하고</SPAN></B></P> <P style="TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">체중을 증가시키고 당뇨병성 혈당을 증가시킴을 입증</SPAN></B></P> <P style="TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> <SPAN> </SPAN> WT--------- </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">정상 쥐<SPAN>(</SPAN>대조군<SPAN>)</SPAN></SPAN></B></P> <P style="TEXT-INDENT: 35pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 2.5" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> BMMC------</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">골수 유래 비만 세포로서<SPAN><SPAN> </SPAN></SPAN></SPAN></B></P> <P style="TEXT-INDENT: 132.15pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 9.44" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> IL-6 INF-</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">γ<SPAN> TNF-a </SPAN>를 모두 분비 못하는 </SPAN></B></P> <P style="TEXT-INDENT: 132.15pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 9.44" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">비만 세포</SPAN></B></P> <P style="TEXT-INDENT: 70pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 5.0" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> Kit<SUP>W-shWsh</SUP>-------</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">비만 세포작용을 없앤 쥐</SPAN></B></P> <P style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> IL-6<SUP> -/- </SUP>BMMC----IL-6 </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">만 분비 못하는 비만세포</SPAN></B></P> <P style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> TNF <SUP>-/-</SUP>BMMC----TNF-</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">α 만 분비 못하는 비만세포</SPAN></B></P> <P style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> INF-</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">α <SUP><SPAN>-/-</SPAN></SUP><SPAN>BMMC-- INF-</SPAN>α 만 분비 못하는 비만세포</SPAN></B></P> <P style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"></SPAN></B> </P> <P style="TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"><IMG src="/_dimg/8%20mst%20며녕ㄱ%20세포usdur.bmp"></SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> [</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">그림<SPAN>] </SPAN>비만 세포는 여러가지<SPAN> Cyotiine </SPAN>을 분비한다 그중에서 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> Interleukin-6 </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">와<SPAN> Inteferon-</SPAN>γ가 비만을 일으킨다</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: aqua; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=3> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt">복부에 혈관 생성 인자 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt"></SPAN></B> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt">Cathepsin</SPAN></B><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt">을 활성화하는 두 물질</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; BACKGROUND: #fabf8f; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid" width=15> <P style="MARGIN: 0cm 0cm 0pt"> </P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: #fde9d9; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" width=607 colSpan=2> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">비만 세포로부터 분비되는</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Interleukin-6 </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">와</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Inteferon-</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">γ 라는 두<SPAN> cytokine</SPAN>이 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">신생 혈관 형성 물질 <SPAN>Cathepsin</SPAN>을 활성화 시킨다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">위 그림에서처럼</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">항 알러지 약은 비만 세포막에 결합하여 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이러한<SPAN> cytokine</SPAN>이 유리되는 것을 억제한다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이는 이들 약이 비만세포로부터</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Histamine</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이 유리되지 못하게 하는 원리와 같다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">항알러지 약은 이 두 <SPAN>Cytokine</SPAN>의 유리를 현저히 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">감소시켜 신생 혈관 형성 물질<SPAN> Cathepsin </SPAN>작용을</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">현저하게 감소시켜 복부 비만을 막는다</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: aqua; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" colSpan=3> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt">비만세포<SPAN>(Mast Cell)</SPAN>는</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt"></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 24pt"></SPAN></B> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 96pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 4.0" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 24pt">다양한 병태에 관련</SPAN></B></P></TD></TR> <TR style="mso-yfti-irow: 13; mso-yfti-lastrow: yes"> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; BACKGROUND: #fabf8f; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid" width=15> <P style="MARGIN: 0cm 0cm 0pt"> </P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: #fde9d9; VERTICAL-ALIGN: middle; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px" width=607 colSpan=2> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">지금까지 비만세포는 천식 등 앨러지를 유발하는</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">면역세포로 알려져 왔다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">그러나 이제는 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">식이성 비만을 유발하는 비만 병태의 주역으로 등장했다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">뿐만 아니라</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">-</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">죽상 동맥경화</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">-</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">동맥류</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">-</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">암</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">-</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">류마티스 관절염</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">-</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">다발성 경화증 등의 병태에도 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">다양하게 관여한다는 사실이 밝혀지고 있다</SPAN></B></P></TD></TR> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes; mso-yfti-lastrow: yes"> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; WIDTH: 20px; BACKGROUND: #fabf8f; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <P style="MARGIN: 0cm 0cm 0pt"> </P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; TEXT-ALIGN: center; BORDER-LEFT: windowtext 1pt solid; WIDTH: 80px; BACKGROUND: #d9d9d9; VERTICAL-ALIGN: middle; BORDER-TOP: windowtext 1pt solid; BORDER-RIGHT: windowtext 1pt solid"> <P style="MARGIN: 0cm 0cm 0pt"><B><SPAN style="FONT-SIZE: 14pt">근거</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-BOTTOM: 30px; PADDING-LEFT: 30px; PADDING-RIGHT: 30px; BACKGROUND: #f2f2f2; VERTICAL-ALIGN: middle; BORDER-TOP: windowtext 1pt solid; BORDER-RIGHT: windowtext 1pt solid; PADDING-TOP: 30px"> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Nature Medicine; 2009 Aug;15(8):940-5. </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><I><SPAN style="COLOR: black; FONT-SIZE: 14pt">Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice</SPAN></I></B><B><I></I></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Jian Liu</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a1#a1"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">1</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, Adeline Divoux</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a2#a2"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">2</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, Jiusong Sun</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a1#a1"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">1</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, Jie Zhang</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a1#a1"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">1</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, Karine Clement</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a2#a2"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">2</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">,</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a3#a3"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">3</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">,</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a4#a4"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">4</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, Jonathan N Glickman</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a1#a1"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">1</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, Galina K Sukhova</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a1#a1"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">1</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, Paul J Wolters</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a5#a5"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">5</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, Juan Du</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a1#a1"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">1</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, Cem Z Gorgun</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a6#a6"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">6</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, Alessandro Doria</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a7#a7"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">7</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, Peter Libby</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a1#a1"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">1</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, Richard S Blumberg</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a1#a1"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">1</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, Barbara B Kahn</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a8#a8"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">8</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, Gokhan S Hotamisligil</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a6#a6"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">6</SPAN></A></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> & Guo-Ping Shi</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A title="affiliated with " href="https://secure.nature.com/nm/journal/vaop/ncurrent/full/nm.1994.html#a1#a1"><SPAN style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none">1</SPAN></A></SPAN></B> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Department of Medicine, Brigham and Women's Hospital and </SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><?xml:namespace prefix = ns0 ns = "urn:schemas-microsoft-com:office:smarttags" /><ns0:PlaceName><SPAN style="COLOR: black">Harvard</SPAN></ns0:PlaceName></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><ns0:PlaceName><SPAN style="COLOR: black">Medical</SPAN></ns0:PlaceName></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><ns0:PlaceType><SPAN style="COLOR: black">School</SPAN></ns0:PlaceType></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, </SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><ns0:City><SPAN style="COLOR: black">Boston</SPAN></ns0:City></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, </SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><ns0:State><SPAN style="COLOR: black">Massachusetts</SPAN></ns0:State></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">, USA</SPAN></B></P></TD></TR></TBODY></TABLE> 이전글다음글 목록
