비타민 D 부족 할 수록 단계적으로 뇌졸중 발생 위험 율도 단계적으로 증가하는 이유 페이지 정보 전성수 0 짧은주소 × 짧은 글주소 복사 Note! 위 주소를 클릭 후, 복사(Ctrl+C)하여 사용하세요. 이전글다음글 목록 본문 <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: red; FONT-SIZE: 18pt">비타민<span> D </span>부족 할 수록 단계적으로 </span></b><b><span style="COLOR: red; FONT-SIZE: 18pt">뇌졸중 발생 확률이 단계적으로 증가하는 이유</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: red; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: red; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: red; FONT-SIZE: 18pt"> <img width="581" height="401" style="WIDTH: 582px; HEIGHT: 518px" src="/_dimg/1%20stroke_isc_web.jpg"></span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: red; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: red; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">허혈성 뇌졸중은 뇌졸중 중에서도 빈도가 가장 높다</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">40</span></b><b><span style="FONT-SIZE: 14pt">대 이상의 한국인은 남자가<span> 3.3% </span>여자가<span> 2.4% </span>발생한다</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">이중 허혈성 뇌졸중은<span> 59%</span>이고 츨혈성 뇌졸중은<span> 41%</span>이다</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">이는<span> 1999</span>년 통계이므로 현재는 더욱 증가하고 있다 </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">허혈성 뇌졸중은 당뇨병 자나 고혈압 자등 처럼 </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">혈관이 혈전으로 인해 막혀 혈류가 통하지 않으므로 인해 </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">동작 장애 감각 장애 언어장애 인지 장애 기억장애를 일으킨다</span></b></p><b><span style="FONT-SIZE: 14pt"> </span></b><p style="MARGIN: 0cm 0cm 0pt"><b><br></b><b><span style="FONT-SIZE: 14pt">이 같은 혀혈성 뇌졸중이 비타민<span> D</span>기 부족할수록 </span></b><b><span style="FONT-SIZE: 14pt">증가한다는 사실이 밝혀 졌다</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">이는 신뢰도가 매우 높은 장기 임상을 통해 입증 되었으며</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">동시에 수행한<span> Meta </span>분석을 통해 그 입증이 확인 되었다</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">이는 덴마크<span> Copenhagen </span>의대 연구팀의 연구 결과이며<span><br></span>그 이유와 함께 신경학 학회지 최근 호를 통해 발표된 내용이다</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt"><img width="685" height="595" style="WIDTH: 686px; HEIGHT: 473px" src="/_dimg/4%20diagram-of-brain-strokes.jpg"> </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0000cc; FONT-SIZE: 18pt">비타민<span> D </span>혈중 농도 적어질수록 단계적으로</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0000cc; FONT-SIZE: 18pt">허혈성 뇌졸중 발병 율도 단계적으로 증가한다</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">본 임상은 덴만크의<span> 30</span>세 이상의 주민<span> 10,170</span>명을 대상으로하여 </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">21</span></b><b><span style="FONT-SIZE: 14pt">년간을 추적 분석 한 결과이다 </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">비타민<span> D </span>의 혈중 농도를 측정하고 </span></b><b><span style="FONT-SIZE: 14pt">최저 농도를 지닌 자와 최고 농도를 지닌 자 사이를</span></b></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><b><span style="FONT-SIZE: 14pt">100 </span></b><b><span style="FONT-SIZE: 14pt">분위<span>(Percentile </span>로 분류 한 후 </span></b><b><span style="FONT-SIZE: 14pt">또다시 아래 표에서 와 같이</span></b></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><b><span style="FONT-SIZE: 14pt">최고 농도 군과 중간 농도 군 과 최하위 농도 군으로 나누고</span></b></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">21</span></b><b><span style="FONT-SIZE: 14pt">년 간 추적 한 결과 비타민<span> D </span>혈중 농도 하위 군은 </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">허렬성 뇌졸중 발생 위험 율이 <span>1.88</span>배 증가 시키고 있었다 </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">또한 허혈성 뇌졸 중 발생에 관여하는 </span></b><b><span style="FONT-SIZE: 14pt">15</span></b><b><span style="FONT-SIZE: 14pt">개 위험 인자를 모두 고려한 후에도<span><br></span>여전히 뇌졸 중 발병 위험을<span> 1,82 </span>배증가시키고 있다</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">따라서 비타민<span> D </span>부족은 뇌졸중을 일으키는 가장 위험 한 인자로 취급해야만 할 것이다</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <table width="652" style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; MARGIN: auto auto auto -1.7pt; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-table-layout-alt: fixed; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" border="1" cellspacing="0" cellpadding="0"> <tbody> <tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <td width="652" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 489.05pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: windowtext 1pt solid; BORDER-RIGHT: windowtext 1pt solid" colspan="9"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">1981</span></b><b><span style="FONT-SIZE: 14pt">년부터<span> 2011</span>년<span> 5</span>월 까지 실시한 허혈성 뇌졸중 발생 율 분석</span></b></p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"> </p></td></tr> <tr style="mso-yfti-irow: 1; mso-row-margin-left: 1.7pt"> <td width="2" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 0cm; PADDING-RIGHT: 0cm; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"> <p style="MARGIN: 0cm 0cm 0pt"> </p></td> <td width="36" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="TEXT-INDENT: -56pt; MARGIN: 0cm 0cm 0pt 56pt; mso-char-indent-count: -4.0"><b><span style="FONT-SIZE: 14pt">군</span></b></p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230"> <p align="center" style="TEXT-ALIGN: center; TEXT-INDENT: -48pt; MARGIN: 0cm 0cm 0pt 48pt; mso-char-indent-count: -4.0"><b><span style="FONT-SIZE: 12pt">100</span></b><b><span style="FONT-SIZE: 12pt">분위</span></b></p></td> <td width="170" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 127.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230" colspan="2"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">비타민 <span>D </span>혈중농도</span></b></p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><font size="2"><b><span>(25(OH)D</span></b><b><span>로서 측정<span>)</span></span></b></font></p></td> <td width="66" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 49.6pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">대상자</span></b></p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">(</span></b><b><span style="FONT-SIZE: 12pt">명<span>)</span></span></b></p></td> <td width="85" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 63.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">뇌졸중</span></b></p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">발생자수</span></b></p></td> <td width="217" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 163pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230" colspan="2"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">뇌졸중 발생위험 비율</span></b></p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt"></span></b> </p></td></tr> <tr style="mso-yfti-irow: 2; mso-row-margin-left: 1.7pt"> <td width="2" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 0cm; PADDING-RIGHT: 0cm; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"> <p style="MARGIN: 0cm 0cm 0pt"> </p></td> <td width="36" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="TEXT-INDENT: -56pt; MARGIN: 0cm 0cm 0pt 56pt; mso-char-indent-count: -4.0"> </p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="TEXT-INDENT: -56pt; MARGIN: 0cm 0cm 0pt 56pt; mso-char-indent-count: -4.0"> </p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">nmol/L</span></b></p></td> <td width="94" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">ng/mL</span></b></p></td> <td width="66" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 49.6pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="MARGIN: 0cm 0cm 0pt"> </p></td> <td width="85" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 63.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="MARGIN: 0cm 0cm 0pt"> </p></td> <td width="95" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc"><font size="2">나이 성별 만</font></span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc"><font size="2">조정 함</font></span></b></p></td> <td width="123" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 92.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="MARGIN: 0cm 0cm 0pt"><font size="2"><b><span style="COLOR: #0066cc">15</span></b><b><span style="COLOR: #0066cc">개 위험 조건 조절 <span>(</span>아래참조<span>)</span></span></b><span style="COLOR: #0066cc"></span></font></p></td></tr> <tr style="mso-yfti-irow: 3; mso-row-margin-left: 1.7pt"> <td width="2" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 0cm; PADDING-RIGHT: 0cm; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"> <p style="MARGIN: 0cm 0cm 0pt"><font size="2"></font> </p></td> <td width="36" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">1</span></b></p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">0-4</span></b></p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">7.5-12</span></b></p></td> <td width="94" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">3-4.8</span></b></p></td> <td width="66" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 49.6pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">480</span></b></p></td> <td width="85" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 63.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">80</span></b></p></td> <td width="95" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">1,88</span></b></p></td> <td width="123" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 92.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">1.82</span></b></p></td></tr> <tr style="mso-yfti-irow: 4; mso-row-margin-left: 1.7pt"> <td width="2" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 0cm; PADDING-RIGHT: 0cm; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"> <p style="MARGIN: 0cm 0cm 0pt"> </p></td> <td width="36" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">2</span></b></p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">5-9</span></b></p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">13-17</span></b></p></td> <td width="94" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">5,2-6.8</span></b></p></td> <td width="66" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 49.6pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">519</span></b></p></td> <td width="85" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 63.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">77</span></b></p></td> <td width="95" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">1.50</span></b></p></td> <td width="123" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 92.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">1.42</span></b></p></td></tr> <tr style="mso-yfti-irow: 5; mso-row-margin-left: 1.7pt"> <td width="2" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 0cm; PADDING-RIGHT: 0cm; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"> <p style="MARGIN: 0cm 0cm 0pt"> </p></td> <td width="36" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">3</span></b></p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">10-24</span></b></p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">18-26</span></b></p></td> <td width="94" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">7.2-10.4</span></b></p></td> <td width="66" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 49.6pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">1,554</span></b></p></td> <td width="85" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 63.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">193</span></b></p></td> <td width="95" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">1.28</span></b></p></td> <td width="123" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 92.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">1.26</span></b></p></td></tr> <tr style="mso-yfti-irow: 6; mso-row-margin-left: 1.7pt"> <td width="2" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 0cm; PADDING-RIGHT: 0cm; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"> <p style="MARGIN: 0cm 0cm 0pt"> </p></td> <td width="36" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">4</span></b></p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">23-49</span></b></p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">28-36</span></b></p></td> <td width="94" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">11.2-14.4</span></b></p></td> <td width="66" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 49.6pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">2,532</span></b></p></td> <td width="85" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 63.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">325</span></b></p></td> <td width="95" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">1.20</span></b></p></td> <td width="123" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 92.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">1.17</span></b></p></td></tr> <tr style="mso-yfti-irow: 7; mso-row-margin-left: 1.7pt"> <td width="2" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 0cm; PADDING-RIGHT: 0cm; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"> <p style="MARGIN: 0cm 0cm 0pt"> </p></td> <td width="36" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">5</span></b></p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">50-100</span></b></p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">47-71</span></b></p></td> <td width="94" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">18.8-28,4</span></b></p></td> <td width="66" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 49.6pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">5,085</span></b></p></td> <td width="85" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 63.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">581</span></b></p></td> <td width="95" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">1.00</span></b></p></td> <td width="123" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 92.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">1.00</span></b></p></td></tr> <tr style="mso-yfti-irow: 8; mso-row-margin-left: 1.7pt"> <td width="2" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 0cm; PADDING-RIGHT: 0cm; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"> <p style="MARGIN: 0cm 0cm 0pt"> </p></td> <td width="36" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt"></span></b> </p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt"></span></b> </p></td> <td width="76" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 2cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">계</span></b></p></td> <td width="94" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="MARGIN: 0cm 0cm 0pt"><span><font size="2"></font></span> </p></td> <td width="66" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 49.6pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">10,170</span></b></p></td> <td width="85" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 63.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">1,256</span></b></p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt">(12.35%)</span></b></p></td> <td width="95" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 70.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="MARGIN: 0cm 0cm 0pt"><span><font size="2"></font></span> </p></td> <td width="123" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 92.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="MARGIN: 0cm 0cm 0pt"><span><font size="2"></font></span> </p></td></tr> <tr style="mso-yfti-irow: 9; mso-row-margin-left: 1.7pt; mso-yfti-lastrow: yes"> <td width="2" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 0cm; PADDING-RIGHT: 0cm; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"> <p style="MARGIN: 0cm 0cm 0pt"><font size="2"></font> </p></td> <td width="36" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 12pt"></span></b> </p></td> <td width="614" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 460.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid; mso-background-themecolor: background2" colspan="7"> <p style="MARGIN: 0cm 0cm 0pt"><b><u><span style="COLOR: red; FONT-SIZE: 12pt">허혈성 뇌졸중 유발에관련 되는 위험 조건</span></u></b><b><u><span style="FONT-SIZE: 12pt">: </span></u></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc"><font size="2">나이<span>. </span>성별<span>, </span>비만도<span>. </span>운동<span>, </span>담배<span>. </span>음주<span>. </span>총콜래스테롤<span>. HDL .</span>고혈압<span>. </span>식이습관<span>. </span>당뇨병<span>. </span></font></span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><font size="2"><span style="COLOR: #0066cc">심방세동<span>. HRT(</span>호르몬요법<span>). </span>지질 저하제 복용<span>. .</span>신장 여과율<span>, </span>등</span></font></b></p></td></tr> <tr height="0"> <td width="2" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"><font size="2"></font></td> <td width="36" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"><font size="2"></font></td> <td width="76" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"><font size="2"></font></td> <td width="76" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"><font size="2"></font></td> <td width="94" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"><font size="2"></font></td> <td width="66" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"><font size="2"></font></td> <td width="85" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"><font size="2"></font></td> <td width="95" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"><font size="2"></font></td> <td width="123" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"><font size="2"></font></td></tr></tbody></table> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt"> <img width="738" height="312" style="WIDTH: 739px; HEIGHT: 434px" src="/_dimg/fig_2.jpg"></span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0000cc; FONT-SIZE: 18pt">비타민<span> D </span>혈중 농도 적은 자가 </span></b><b><span style="COLOR: #0000cc; FONT-SIZE: 18pt">나이가 많아 질수록 </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0000cc; FONT-SIZE: 18pt">허혈성 뇌졸중 발병 율도 비례하여 더 증가한다</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt"><span style="FONT-SIZE: 14pt"> 위 그</span>림에서 처럼 비타민<span> D </span>가 적은 자가 </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt"> 나이</span></b><b><span style="FONT-SIZE: 14pt">가 많아 질수 록 </span></b><b><span style="FONT-SIZE: 14pt">허혈성 뇌졸중 발병 율도 중가 한다</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt"><img width="693" height="333" style="WIDTH: 694px; HEIGHT: 543px" src="/_dimg/5%20cv.gif"></span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt">지금 까지 발표된 모든 임상을 종합 한 결과도</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt">비타민<span> D </span>부족 할 수록 허혈성 뇌졸중이 증가했다</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">본 주제와 관련히여 <span>2011</span>년 까지 전세계적으로 발표된<span><br></span>객관적 임상은<span> 10</span>건 이 였다<span>. </span>이를 종합 분석 해본 결과는</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">아래 표 와 같이 </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">비타민<span> D </span>혈중 농도가 최하위 층은 최고 위 층에 비하여<span><br></span>모든 조건을 조정한 후에 나타난 </span></b><b><span style="FONT-SIZE: 14pt">허 혈성 뇌졸중 발병 비교 위험도가<span> 1.54 </span>배로 나타 났다</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <table style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" border="1" cellspacing="0" cellpadding="0"> <tbody> <tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <td width="565" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 423.6pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: windowtext 1pt solid; BORDER-RIGHT: windowtext 1pt solid" colspan="2"> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">비타민<span> D </span>혈중 농도 최하위 자의 허혈성 뇌졸중 발병 비교 율</span></b></p></td></tr> <tr> <td width="310" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 232.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">대상자 총수<span><span> </span></span></span></b></p></td> <td width="255" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 191.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">58,384 </span></b><b><span style="FONT-SIZE: 14pt">명</span></b></p></td></tr> <tr> <td width="310" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 232.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">허혈성 뇌졸중 발생 자</span></b></p></td> <td width="255" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 191.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">2,644</span></b><b><span style="FONT-SIZE: 14pt">명<span> (4.53%)</span></span></b></p></td></tr> <tr style="mso-yfti-irow: 3; mso-yfti-lastrow: yes"> <td width="310" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: windowtext 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 232.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">최고 농도 지닌 자 보다</span></b></p></td> <td width="255" style="BORDER-BOTTOM: windowtext 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 191.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: windowtext 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">1.54 </span></b><b><span style="FONT-SIZE: 14pt">배</span></b></p></td></tr></tbody></table> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">이로서 비타민<span> D </span>가 부족할수록 </span></b><b><span style="FONT-SIZE: 14pt">허혈성 뇌졸중은 역 비례하여 </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">단계적으로 증가한다는 사실이 </span></b><b><span style="FONT-SIZE: 14pt">증 확인 된 셈이다</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="TEXT-INDENT: 40pt; MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt"></span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt"><img width="714" height="588" style="WIDTH: 715px; HEIGHT: 783px" src="/_dimg/8%20gene%20express.jpg"></span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt"></span></b> </p><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt"> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L">[</span></b><b><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L">그림<span>] </span>비타민 <span>D </span>허루 <span>2000 IU </span>복용군과 하루 <span>400IU </span>복용군이 </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L"> 2 개월 </span></b><b><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L"></span></b><b><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L">복용 후에 나타난 유전 자의 활성도의 차이를 보여주는 유전자 도표.</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L"></span></b> </p> <p style="TEXT-INDENT: 56pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 4.0"><b><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L">비타민 <span>D </span>는 <span>291 </span>개 유전자에 직용며 이들 유전자는<span> </span></span></b></p> <p style="TEXT-INDENT: 56pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 4.0"><b><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L">주로 면역계 순환기계 종양계 스트레스등임이 </span></b><b><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L">유전자 <span>Microarray </span>기법으로 확인 되었다</span></b></p> <p style="TEXT-INDENT: 56pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 4.0"><b><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L"></span></b> </p> </span></b><p style="MARGIN: 0cm 0cm 0pt"><b></b><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt">비타민<span> D </span>가 허혈성 뇌졸 중 발생을 예방 할 수 있는 이유</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: #0066cc; FONT-SIZE: 18pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">1 </span></b><b><span style="FONT-SIZE: 14pt">고혈압이 허혈성 뇌졸중을 유발한다는 것은 주지의 사실인 바 </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">비타민<span> D </span>는 유전자에 작용하여 혈압을 상승 시키는 </span></b></p> <p style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt"> </p> <p style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Renin </span></b><b><span style="FONT-SIZE: 14pt">을 증가시켜 고혈압을 악화시키므로서 </span></b><b><span style="FONT-SIZE: 14pt">허혈성 뇌졸중을 간접 유발 한다 </span></b></p> <p style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt"> </p> <p align="left" style="LINE-HEIGHT: 12pt; TEXT-INDENT: -35pt; MARGIN: 0cm 0cm 0pt 45pt; mso-char-indent-count: -3.5"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red">[</span></b><b><span style="COLOR: red; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">근거</span></b><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red">] </span></b><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK">J Steroid Biochem Mol Biol 2004;89–90:387–392. Vitamin D: a negative endocrine regulator </span></b></p> <p align="left" style="LINE-HEIGHT: 12pt; TEXT-INDENT: -35pt; MARGIN: 0cm 0cm 0pt 45pt; mso-char-indent-count: -3.5"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"> of the renin-angiotensin system and blood pressure</span></b><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; mso-bidi-font-family: AdvAVENIR-BK">.</span></b><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red"> </span></b><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK">Uskokovic M, et al</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">2 </span></b><b><span style="FONT-SIZE: 14pt">죽상 동맥 경화나 부정맥<span>(</span>심방 세동<span>)</span>도 혈전 괴를 뇌혈관으로 </span></b></p> <p style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">박출 시켜 뇌 혈류를 막아버리는 뇌 색전을 유발하여 </span></b></p> <p style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt"><span> </span></span></b><b><span style="FONT-SIZE: 14pt">허혈성 뇌졸중을 유발한다는 사실도 주지의 사실인바</span></b></p> <p style="MARGIN: 0cm 0cm 0pt"> </p> <p style="TEXT-INDENT: -7pt; MARGIN: 0cm 0cm 0pt 22pt; mso-char-indent-count: -.5; mso-para-margin-left: 1.5gd"><b><span style="FONT-SIZE: 14pt">비타민<span> D </span>는 유전자에 작용하여 혈전 형성 인자인 </span></b></p> <p style="TEXT-INDENT: -7pt; MARGIN: 0cm 0cm 0pt 22pt; mso-char-indent-count: -.5; mso-para-margin-left: 1.5gd"><b><span style="FONT-SIZE: 14pt"><span>Thrombomodulin </span>생성을 억제하고 </span></b></p> <p style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">혈전 용해 인자인 조직 인자<span>(Tissue Factor) </span>생성을 증가시켜 </span></b><b><span style="FONT-SIZE: 14pt">혈전 형성을 억제한다</span></b></p> <p style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt"> </p> <p align="left" style="TEXT-INDENT: -50pt; MARGIN: 0cm 0cm 0pt 65pt; mso-para-margin-left: 1.5gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red">[</span></b><b><span style="COLOR: red; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana">근거</span></b><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red">] 1)</span></b><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"> Circulation 2000;102:2867–2872.DihydroxyvitaminD (3) and its potent synthetic analogs</span></b></p> <p align="left" style="TEXT-INDENT: -50pt; MARGIN: 0cm 0cm 0pt 65pt; mso-para-margin-left: 1.5gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"> downregulate tissue factor and upregulate thrombomodulin expression in monocytic cells, </span></b></p> <p align="left" style="TEXT-INDENT: -50pt; MARGIN: 0cm 0cm 0pt 65pt; mso-para-margin-left: 1.5gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"> counteracting the effects of tumor necrosis factor and oxidized LDL. Yamamoto K, et al.</span></b></p> <p align="left" style="TEXT-INDENT: -25pt; MARGIN: 0cm 0cm 0pt 75pt; mso-char-indent-count: -2.5; mso-para-margin-left: 5.0gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK">2) J Biol Chem 2004;279:35798–35802.Disruption of nuclear vitamin D Receptor gene causes </span></b></p> <p align="left" style="TEXT-INDENT: -25pt; MARGIN: 0cm 0cm 0pt 75pt; mso-char-indent-count: -2.5; mso-para-margin-left: 5.0gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"> enhanced thrombogenicity Akaike M, et al </span></b></p> <p align="left" style="TEXT-INDENT: -10pt; MARGIN: 0cm 0cm 0pt 58pt; mso-para-margin-left: 4.8gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK">3) JVasc Res 2007;44:11–18 Vitamin D analogs modulate the expression of plasminogen activator</span></b></p> <p align="left" style="TEXT-INDENT: -10pt; MARGIN: 0cm 0cm 0pt 58pt; mso-para-margin-left: 4.8gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"> inhibitor-1, thrombospondin-1 and thrombomodulin in human aortic smooth muscle cells, Nakane M,et al</span></b></p> <p align="left" style="TEXT-INDENT: -10pt; MARGIN: 0cm 0cm 0pt 58pt; mso-para-margin-left: 4.8gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"></span></b> </p> <p align="left" style="TEXT-INDENT: -10pt; MARGIN: 0cm 0cm 0pt 58pt; mso-para-margin-left: 4.8gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"></span></b> </p> <p align="left" style="TEXT-INDENT: -10pt; MARGIN: 0cm 0cm 0pt 58pt; mso-para-margin-left: 4.8gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"></span></b> </p> <p align="left" style="TEXT-INDENT: -10pt; MARGIN: 0cm 0cm 0pt 58pt; mso-para-margin-left: 4.8gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"></span></b> </p> <p align="left" style="TEXT-INDENT: -10pt; MARGIN: 0cm 0cm 0pt 58pt; mso-para-margin-left: 4.8gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"></span></b> </p> <p align="left" style="TEXT-INDENT: -10pt; MARGIN: 0cm 0cm 0pt 58pt; mso-para-margin-left: 4.8gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"><img src="/_dimg/Vitamin%20D%20lympho.jpg"></span></b></p> <p align="left" style="TEXT-INDENT: -10pt; MARGIN: 0cm 0cm 0pt 58pt; mso-para-margin-left: 4.8gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK">[</span></b></p><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"> <p style="MARGIN: 0cm 0cm 0pt"><font face="맑은 고딕"><span><strong> <font size="4"> [그림<span>] </span>비타민 <span>D</span>가 죽종 이나 혈전 형성 을 억제하는 경로</font></strong></span></font></p> <p style="MARGIN: 0cm 0cm 0pt"><font face="맑은 고딕"><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L"></span></font> </p> <p style="MARGIN: 0cm 0cm 0pt"><font face="맑은 고딕"><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L"></span></font> </p> <p style="MARGIN: 0cm 0cm 0pt"><font face="맑은 고딕"><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L"></span></font> </p></span> <p align="left" style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">3,</span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">심장 동맥에 형성된 죽종이 혈액중에 존재하는 </span></b></p> <p align="left" style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"> </span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">비타민<span>D</span>의 중간 활성체<span> 25(OH)D </span>를 감소 시키므로 </span></b></p> <p align="left" style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"></span></b> </p> <p align="left" style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">경동맥에 혈전 형성을 유발하여 이로인해 </span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">허혈성 뇌졸 중이 증가한다는 사실은 </span></b></p> <p align="left" style="MARGIN: 0cm 0cm 0pt 10pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"> 아직 학자들 간에 갑론 을박의 대상이지만 검토 할 만 하다 </span></b></p> <p align="left" style="MARGIN: 0cm 0cm 0pt 10pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"></span></b> </p> <p align="left" style="TEXT-INDENT: 10pt; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK">[</span></b><b><span style="COLOR: red; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana; mso-bidi-font-family: AdvAVENIR-BK">근거</span></b><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK">] 1) Atherosclerosis 2009;207:585–590.. Serum vitamin D, parathyroid</span></b></p> <p align="left" style="TEXT-INDENT: 60pt; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK">hormone levels, and carotid atherosclerosis.</span></b><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: #231f20; mso-bidi-font-family: AdvAVENIR-BK"> </span></b><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK">Michos ED, et al </span></b></p> <p align="left" style="TEXT-INDENT: 40pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 4.0"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK">2) Calcif Tissue Int 2009;84:423–424. 25-hydroxyvitamin D is not</span></b></p> <p align="left" style="MARGIN: 0cm 0cm 0pt 55pt; mso-para-margin-left: 5.5gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK">associated with carotid intima-media thickness in older</span></b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"> men and women Snijder et al. </span></p> <p align="left" style="MARGIN: 0cm 0cm 0pt 55pt; mso-para-margin-left: 5.5gd"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"></span> </p> <p align="left" style="MARGIN: 0cm 0cm 0pt 55pt; mso-para-margin-left: 5.5gd"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"></span> </p> <p align="left" style="MARGIN: 0cm 0cm 0pt 55pt; mso-para-margin-left: 5.5gd"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"></span> </p> <p align="left" style="MARGIN: 0cm 0cm 0pt 55pt; mso-para-margin-left: 5.5gd"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"></span> </p> <p align="left" style="MARGIN: 0cm 0cm 0pt 55pt; mso-para-margin-left: 5.5gd"><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"></span> </p> <p align="left" style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">4 </span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">염증 병태가 허혈 성 뇌졸중의 유발<span><span> </span></span>인자임이 제안되어 왔다</span></b></p> <p align="left" style="MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"></span></b> </p> <p align="left" style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt 10pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">비타민<span> D </span>가 부족하면 염증이 악화된다는 것은 주지의 사실이다</span></b></p> <p align="left" style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt 10pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"></span></b> </p> <p align="left" style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt 10pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">따라서 염증 억제 작용을 통해서도 </span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">비타민<span> DR</span>가 허혈 성 뇌졸중 억제 할 수 있다</span></b></p> <p align="left" style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt 10pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"></span></b> </p> <p align="left" style="TEXT-INDENT: -30pt; MARGIN: 0cm 0cm 0pt 50pt; mso-para-margin-left: 2.0gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK">[</span></b><b><span style="COLOR: red; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana; mso-bidi-font-family: AdvAVENIR-BK">근거</span></b><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK">] Arterioscler Thromb Vasc Biol 2010;30:2317–2319 Vitamin D3 suppresses immune reactions i</span></b></p> <p align="left" style="TEXT-INDENT: -30pt; MARGIN: 0cm 0cm 0pt 50pt; mso-para-margin-left: 2.0gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"> atherosclerosis,affecting regulatory T cells and dendritic cell function.Bobyshev</span></b></p> <p align="left" style="TEXT-INDENT: -30pt; MARGIN: 0cm 0cm 0pt 50pt; mso-para-margin-left: 2.0gd"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"></span></b> </p> <p align="left" style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt 10pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"></span></b> </p> <p align="left" style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt 10pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"><img width="684" height="300" style="WIDTH: 685px; HEIGHT: 438px" src="/_dimg/6%20혈전%20용해.gif"></span></b></p> <p align="left" style="TEXT-INDENT: 14pt; MARGIN: 0cm 0cm 0pt 10pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"></span></b> </p> <p align="left" style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 24pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"><font size="2"> </font><font size="4"> <font color="#ff0000">[그림<span>] </span>비타민 <span>D</span>가 죽종 이나 혈전 형성 을 억제하는 경로</font></font></span></b></p><b> <p style="MARGIN: 0cm 0cm 0pt"><font face="맑은 고딕"><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAVENIR-L"></span></font> </p></b> <p align="left" style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 24pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"></span></b> </p> <p align="left" style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 24pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">5 </span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">비타민<span> D </span>부족이 허혈성 심장 병을 유발하는 위험 인자라는 사실도 </span></b></p> <p align="left" style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 24pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"> 이미 발표된 바 있으며 그 원리가 허혈성 뇌졸 중을 </span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">유발하는 이유 와 같을 수 있다</span></b></p> <p align="left" style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 24pt"><span style="FONT-FAMILY: 'Verdana','sans-serif'; mso-bidi-font-family: AdvAVENIR-BK"></span> </p> <p align="left" style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 24pt"><span style="FONT-FAMILY: 'Verdana','sans-serif'; mso-bidi-font-family: AdvAVENIR-BK"> [</span><b><span style="COLOR: red; mso-ascii-font-family: Verdana; mso-hansi-font-family: Verdana; mso-bidi-font-family: AdvAVENIR-BK">근거</span></b><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK">] Circulation 2008;117:503–511.Vitamin D deficiency and risk of cardiovascular disease. Booth SL, et al </span></b></p> <p align="left" style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 24pt"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"></span></b> </p> <p align="left" style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 24pt"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"></span></b> </p> <p align="left" style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 24pt"><b><span style="FONT-FAMILY: 'Verdana','sans-serif'; COLOR: red; mso-bidi-font-family: AdvAVENIR-BK"></span></b><b><span style="COLOR: red; FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"></span></b> </p> <p align="left" style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 24pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">6 </span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R">비타민<span> D </span>부족이 말초 혈관 질환을 유발하는 위험 인자라는 사실도 </span></b></p> <p align="left" style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 24pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvAGaramond-R"> 이미</span></b></p> 이전글다음글 목록
