벤조디아제핀 계 약물 장기 복용하면 약물 내성으로 인해 복용 량이 어느 정도 까지 증가하게 되나 > 최신 임상 뉴스

벤조디아제핀 계 약물 장기 복용하면 약물 내성으로 인해 복용 량이 어느 정도 까지 증가하게 되나

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벤조디아제핀 계 약물 장기 복용하면 
 
약물 내성으로 인해 
 
 
복용 량이 어느 정도 까지 증가하게 되나
 
벤조디아젠핀 계 약물을 장기 간  복용하면 
습관 성과 약물 내성으로 인해
복용 량이 계속 증가하는 것으로 알려져 왔다
 
과연 얼마나 증가 하는가에 대한 임상 결과가 밝혀졌다 
 
이는 네델랜드 Nizmegen 의대 연구 팀의 연구 결과이며 
가정 의학 학술 저널 최신 호를 통해  발표된 내용이다
 
 
<img width="534" height="224" style="WIDTH: 536px; HEIGHT: 540px" src="/_dimg/1%20benzo.jpg">
 
[그림] Benzodiazepine 수용체 : BZD 에 결합하여 작용
 
 
장기 복용해도 약 용량 증가 거의 없다
 
Diazepam, Temazepam 같은 벤조디아제핀 계 약물을 
6개월 이상 계속 복용하는 자 1,105명을 대상으로하여 
매 3개월 마다 2년 간을 추적 조사 해 본 결과
아래 표에서 처럼 
대부분의 복용 자들에게서 용량 증가가 없다는 
놀라운 사실이 밝혀졌다 
 
 
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<tbody>
<tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes">
<td width="234" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 175.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230" colspan="2">
대상자 </td>
<td width="189" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" colspan="2">
1,105명
(여자72.9%)</td></tr>
<tr>
<td width="234" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 175.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230" colspan="2">
나이</td>
<td width="189" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" colspan="2">
64.4 세</td></tr>
<tr>
<td width="423" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 317.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="4">
복용약(%)</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
Diazepam</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
9%</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
Oxazepam</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
20.9%</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
Temazepam</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
18.25%</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
기타 Benzodiazepin</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
32.0%</td></tr>
<tr style="mso-yfti-irow: 7; mso-yfti-lastrow: yes">
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
항우울제 병용</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
18.7%$</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"></td>
<td width="198" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"></td>
<td width="9" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"></td>
<td width="180" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"></td></tr></tbody></table>
 
<table style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" border="1" cellspacing="0" cellpadding="0">
<tbody>
<tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes">
<td width="423" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 317.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" colspan="3">
매 3 개월 처방 량</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
0-3 개월 처방 </td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
86.9 일 분</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
3-6 개월 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
84.5 일 분</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
6-9 개월 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
85.8 일 분</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
9-12 개월 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
86.1 일 분</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
12-15 개월 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
85.1 일 분</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
15-18 개월 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
84.4 일 분</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
18-21 개월 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
87.6 일 분</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
21-24 개월 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
86.6 일 분</td></tr>
<tr style="mso-yfti-irow: 9; mso-yfti-lastrow: yes">
<td width="243" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 182.6pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
매월 평균 증가 계수</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
0.034(무의미)</td></tr></tbody></table>
 
 
 
 
 
 
복용 량이 정상 수준 보다 약간 높 은 자들 
 
벤조디아제핀 계의 정상적 복용 량은 
Diazepam 1 일 10mg 이며 
노인의 경우는 이 수준 보다 2배를 초과하지 않해야하며
젊은 이의 경우는 이 수준 보다 3배를 초과하지 않헤야하며
복용 기간은 4주를 넘지 않해야한다
 
그러나 본 임상에서는 모두가 기준 량에 대해 2배를 
초과하지 않고 있으나 
복용 기간은 모두가 4주를 초과하여
2년 이상을 장기 복용하고 있는 자들이다
따라서 복용량이 정상 수준을 1배이상 2배이하 초과한 자를을
분석 한 결과 아래 표에서 처럼 
이들은 주로 증상이 심한 자로서 항 우울 제를 병용하는 자들이며
불안증와 불면증을 합병한 자들임이 밝혀 졌다
 
즉 약물 내성으로 인한 복용량 증가가 아니라는 의미다.
 
  
 
<table style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" border="1" cellspacing="0" cellpadding="0">
<tbody>
<tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes">
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid">
정상 수준의 
처방량 복용 자</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid">
1배이상 2배이하의
처방량 복용 자</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
나이</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
65.3 세</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
60.6 세</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
불안 증으로 처방 </td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
48.9%</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
40.0%</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
불면 증으로 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
35.3%</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
21.0%</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
불안증과 불면증 </td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
17. %</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
39.0%</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
항우울 제 병용 자 </td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
16.7%</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
36.5%</td></tr>
<tr>
<td width="603" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 451.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="4">
매 3 개월 처방 량</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
0-3 개월 처방 </td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
64.0 일 분</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
258.8 일 분</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
3-6 개월 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
65.7 일 분</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
221.7 일 분</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
6-9 개월 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
64.7 일 분</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
239.0 일 분</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
9-12 개월 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
65.2 일 분</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
237.2 일 분</td></tr>
<tr>
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
12-15 개월 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
63.7 일 분</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
238.7 일 분</td></tr>
<tr style="HEIGHT: 21.25pt; mso-yfti-irow: 12">
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; HEIGHT: 21.25pt; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; HEIGHT: 21.25pt; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
15-18 개월 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; HEIGHT: 21.25pt; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
64.0 일 분</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; HEIGHT: 21.25pt; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
235.0 일 분</td></tr>
<tr style="HEIGHT: 28.1pt; mso-yfti-irow: 13">
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; HEIGHT: 28.1pt; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; HEIGHT: 28.1pt; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
18-21 개월 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; HEIGHT: 28.1pt; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
66.0 일 분</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; HEIGHT: 28.1pt; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
239.4 일 분</td></tr>
<tr style="mso-yfti-irow: 14; mso-yfti-lastrow: yes">
<td width="36" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 26.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
21-24 개월 처방</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
67.1 일 분</td>
<td width="180" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
224.,3 일 분</td></tr></tbody></table>
 
 
 
[근거]
<a title="Family practice." href="http://www.ncbi.nlm.nih.gov/pubmed/23515374">Fam Pract.</a> 2013 Aug;30(4):404-10. doi: 10.1093/fampra/cmt010.
 Epub 2013 Mar 20.Author Affiliations<a name="aff-1"></a>Department of Primary and Community Care, 
Radboud University Nijmegen Medical Centre, Nijmegen, <a name="aff-2"></a>University Center for Psychiatry 
& Interdisciplinary Center for Psychopathology of Emotion Regulation,
University Medical Center Groningen, Groningen, and <a name="aff-3"></a> Scientific Institute
for Quality of Healthcare (IQ Healthcare), Radboud University Nijmegen Medical Centre,
 Nijmegen, The Netherlands.