비타민 A ,베타-카로틴, Vit-E Vit-C, Selenium 5 대 항 산화 제 약효 평가 > 최신 임상 뉴스

비타민 A ,베타-카로틴, Vit-E Vit-C, Selenium 5 대 항 산화 제 약효 평가

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비타민 A ,베타-카로틴, Vit-E  Vit-C,  Selenium
5 대 항 산화 제 약효 평가  
 
 
<img src="http://holytree.co.kr/_dimg/thumb-antioxidant_600x344.jpg" alt=""/>
 
[그림] 항 산화제란 대부분의 질환을 유발시키는 유해산소에
전자 한개를 보충 시켜 주어 유해 산소를 안전한 산소로 
전환시키는 물질을 말한다
 
 
비타민 A, 베타-카로틴, 
비타민-E
비타민-C
Selenium 
이상 5대 항 산화제에 대한 약효 평가 결과가 발표되었다
 
이들 항 산화제를 평균 년령 63세의 건강한 자가 
3년기간 동안 복용 했을 때
모든 병으로 인한 사망 율을 어느 정도 감소 시킬 수 있는지 
또는 오히려 어느 정도는 사망 율을 더 높이는지를 평가한 내용이다
 
 
이는 덴마크 코펜하겐 의대 연구팀의 메타 분석 결과이며
미국 의사 회 학술 지 최신 호(JAMA)를 통해 발표된 내용이다
 
 
 
 
사망 율 감소 효과 없다
 
본 연구는 약 50만 명에 대하여 실시된 56편의 임상 결과를 
메타분석 환 것이며 그 결과는 위 그림과 아래 표에서 처럼 
모두가 다 모든 병에 의한 사망 률 감소 효과가 없는 것으로 나타났다
 
 
 

<table width="631" style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; WIDTH: 473.2pt; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" border="1" cellspacing="0" cellpadding="0">
<tbody>
<tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes">
<td width="631" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 473.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" colspan="8">
Placebo 와 비교한 사망률 감소 비교 위험율</td></tr>
<tr>
<td width="92" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 69.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2">
 </td>
<td width="61" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 46.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2">
임상</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2">
대상자</td>
<td width="154" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 115.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" colspan="2">
항산화제 복용</td>
<td width="154" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 115.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" colspan="2">
Placebo 복용</td>
<td width="93" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 69.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" rowspan="2">
사망 감소
비교 위험</td></tr>
<tr>
<td width="92" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 69.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="61" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 46.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
사망자</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
참가자</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
시밍자</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fbd4b4; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
참가자</td></tr>
<tr>
<td width="92" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 69.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
베타키로친</td>
<td width="61" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 46.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
26</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
173,006</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
13,202</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
96,003</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
8,556</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
77.003</td>
<td width="93" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 69.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
1.05</td></tr>
<tr>
<td width="92" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 69.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
비타민 A</td>
<td width="61" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 46.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
12</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
41.144</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
3,444</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
24,596</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
2,249</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
16,548</td>
<td width="93" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 69.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
1.07</td></tr>
<tr>
<td width="92" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 69.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
비타민 E</td>
<td width="61" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 46.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
46</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
171,244</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
11,689</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
97,523</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
7,561</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
73,721</td>
<td width="93" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 69.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
1.03</td></tr>
<tr>
<td width="92" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 69.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
비타민 C</td>
<td width="61" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 46.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
29</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
65.942</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
3,637</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
36,659</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
2.717</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
29,283</td>
<td width="93" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 69.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
1.02</td></tr>
<tr style="mso-yfti-irow: 7; mso-yfti-lastrow: yes">
<td width="92" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 69.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
Selenium</td>
<td width="61" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 46.1pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
17</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
62,740</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
2,670</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
39,779</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
1,468</td>
<td width="77" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 57.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
22,961</td>
<td width="93" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 69.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
0.97</td></tr></tbody></table> 
 
 
 
그러나 이들 비타민의 진정한 효과를 판정하려면 
비타민 결핍 자 중에서 특별한 질병 별로 
병세의 악화 감소 율을 확인하는 장기적 임상을 해 보아야 할것이다
 
 
[근거]
JAMA  <a href="http://jama.jamanetwork.com/issue.aspx?journalid=67&issueid=927619">September 18, 2013, Vol 310, No. 11</a>
Antioxidant Supplements to Prevent Mortality 
1The Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, 
Centre for Clinical Intervention Research, Rigshospitalet, 
Copenhagen University Hospital, Copenhagen, Denmark