알즈하이머 병을 치료하는 비타민 E 기존 약 보다 우수 페이지 정보 전성수 0 짧은주소 × 짧은 글주소 복사 Note! 위 주소를 클릭 후, 복사(Ctrl+C)하여 사용하세요. 이전글다음글 목록 본문 <p style="MARGIN: 0cm 0cm 0pt"><span style="COLOR: red; FONT-SIZE: 18pt"><strong></strong></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><span style="COLOR: red; FONT-SIZE: 18pt"><strong>알즈하이머 병 예방 </strong></span></p> <p style="MARGIN: 0cm 0cm 0pt"><span style="COLOR: red; FONT-SIZE: 18pt"><strong></strong></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><span style="COLOR: red; FONT-SIZE: 18pt"><strong>비타민<span> E </span>대 단위 임상으로 입증<span>(</span>미국<span> 14</span>개 년구소<span>)</span></strong></span></p> <p style="MARGIN: 0cm 0cm 0pt"><span style="COLOR: red; FONT-SIZE: 18pt"><strong></strong></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><span style="COLOR: red; FONT-SIZE: 18pt"><strong></strong></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><span style="COLOR: red; FONT-SIZE: 18pt"><strong><span><img width="515" height="195" style="WIDTH: 514px; HEIGHT: 363px" src="/_dimg/3-%20alzimagesCA5G9BTH.jpg"></span></strong></span></p> <p style="MARGIN: 0cm 0cm 0pt"><span style="COLOR: #0070c0; FONT-SIZE: 18pt"><strong></strong></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><strong><font color="#ff0000" size="3">[그림] 유해 산소에 의해 산화되어 기억 세포가 파괴되는 모습</font></strong></p> <p style="MARGIN: 0cm 0cm 0pt"><strong><font color="#ff0000" size="3"></font></strong> </p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong></strong></font> </p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong></strong></font> </p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong>대 단위 임상 연구 결과 비타민<span> E (</span>알파 토코페롤<span>)</span>가 </strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong>기존 알즈아이머 병 치료 제 보다 월씬 우수함이 입증 되었다</strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><span><font size="5"><strong></strong></font></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong>이는 미국<span> 14</span>개 알즈하이머 병 전문 연구 기관의 무 작위 </strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong>이중 맹검 대단위 비교 임상 결과이며 </strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong>미국 의사 회 학술지 최신 호를 통해 밝표 된 내용이다</strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong><span>Time </span>지를 통해서도 대서 특필 되었다</strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><span><font size="5"><strong></strong></font></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><span><strong><font size="5"></font></strong></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><span><strong><font size="5"></font></strong></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><span><strong><font size="5"></font></strong></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><span><strong><font size="5"><span><font size="5"><strong><span><strong><font size="5"><img width="528" height="207" style="WIDTH: 524px; HEIGHT: 505px" src="/_dimg/1-electron.jpg"></font></strong></span></strong></font></span></font></strong></span></p> <p style="MARGIN: 0cm 0cm 0pt"><span><strong><font color="#ff8080" size="3">[그림 유해 산소를 제거하는 비타민 E의 항산화 작용</font></strong></span></p> <p style="MARGIN: 0cm 0cm 0pt"><span><strong><font size="5"></font></strong></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><span><strong><font size="5"></font></strong></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><span><strong><font size="5"></font></strong></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong>비타민<span> E </span>하루<span> 2,000 IU </span>복용의<span><span> </span></span>효과</strong></span></p> <p style="MARGIN: 0cm 0cm 0pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong></strong></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong></strong></font> </p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong>\본 임상은 알즈하이머 병 환자<span> 561</span>명 을<span> 4 Group</span>으로 나누어 </strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong><span>2007</span>년 부터<span> 2012</span>년 까지 무 작위 이중 맹검 임상을 실시하므로서 </strong></font><span><br></span><font size="5"><strong>현재 중등도 내지 중증에 널리 사용되고 있는<span> Memantine </span>보다</strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong>비타민<span> E </span>의 효과가 휠씬 우수 함을 입증하였다</strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><span><font size="5"><strong></strong></font></span> </p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong>아래 표에서 처럼 </strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong><span>Group 1</span>은 비타민<span> E 2,000IU</span>를 매일 복용하였고</strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong><span>Gourp 2</span>는 <span>Memantine 20mg </span>을 매일 복용하였고</strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong><span>Group 3 </span>은<span> Memantine 20mg + </span>비타민<span> E 2000IU </span>를 복용하였고</strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><font size="5"><strong><span>Griup<span> </span>4</span>는<span><span> </span>Placebo </span>를 복용하였다 </strong></font></p> <p style="MARGIN: 0cm 0cm 0pt"><span><font size="5"><strong></strong></font></span> </p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><font size="5"><strong>단 모든<span> Group </span>에게는 경중 과 중등도에 허가된<span> Acetylcholine </span>증</strong></font></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><font size="5"><strong>강제인<span> Donepezil </span>과<span> Galantamine</span>을 복용케하였다</strong></font></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><span><font size="5"><strong></strong></font></span> </p> <table width="650" style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; MARGIN: auto auto auto 14pt; WIDTH: 487.55pt; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" border="1" cellspacing="0" cellpadding="0"> <tbody> <tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" rowspan="2"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>알즈하인머</strong></span></p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>지수</strong></span></p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>ADCS-ADL</strong></span></p></td> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Group1 </strong></span></p></td> <td width="124" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 93.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Group2</strong></span></p></td> <td width="189" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 142pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Group3</strong></span></p></td> <td width="104" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Group4</strong></span></p></td></tr> <tr> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Vitamin E</strong></span></p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>2,000 IU</strong></span></p></td> <td width="124" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 93.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Memantine</strong></span></p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>20mg </strong></span></p></td> <td width="189" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 142pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Memantine 20mg</strong></span></p> <p style="TEXT-INDENT: 6pt; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Vitamin E 2,000 IU </strong></span></p></td> <td width="104" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Placebo</strong></span></p></td></tr> <tr> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p></td> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><strong><span style="FONT-SIZE: 12pt">140 </span><span style="FONT-SIZE: 12pt">명</span></strong></p></td> <td width="124" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 93.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><strong><span style="FONT-SIZE: 12pt">142</span><span style="FONT-SIZE: 12pt">명</span></strong></p></td> <td width="189" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 142pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><strong><span style="FONT-SIZE: 12pt">139</span><span style="FONT-SIZE: 12pt">명</span></strong></p></td> <td width="104" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><strong><span style="FONT-SIZE: 12pt">140</span><span style="FONT-SIZE: 12pt">명</span></strong></p></td></tr> <tr> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>초기 중상</strong></span></p></td> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>57.20</strong></span></p></td> <td width="124" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 93.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>57.77</strong></span></p></td> <td width="189" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 142pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>57.16</strong></span></p></td> <td width="104" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>56.93</strong></span></p></td></tr> <tr> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Placebo</strong></span></p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>비교 개선도</strong></span></p></td> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>3.5</strong></span></p></td> <td width="124" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 93.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>1.98</strong></span></p></td> <td width="189" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 142pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>1.76</strong></span></p></td> <td width="104" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>1</strong></span></p></td></tr> <tr style="mso-yfti-irow: 5; mso-yfti-lastrow: yes"> <td width="650" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 487.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="5"> <p style="MARGIN: 0cm 0cm 0pt"><strong><span style="FONT-SIZE: 12pt">-Memantine : </span><span style="FONT-SIZE: 12pt">중등도 내지 중증에 사용하는 알즈하이머 병 약</span></strong></p> <p style="TEXT-INDENT: -6pt; MARGIN: 0cm 0cm 0pt 6pt; mso-char-indent-count: -.5"><strong><span style="FONT-SIZE: 12pt">-</span><span style="FONT-SIZE: 12pt">모든<span> 4 Group</span>에는 경증 내지 중등도에 사용하는 </span></strong></p> <p style="TEXT-INDENT: 12pt; MARGIN: 0cm 0cm 0pt"><strong><span style="FONT-SIZE: 12pt">Donepezil </span><span style="FONT-SIZE: 12pt">과<span> Galasntamine </span>을 복용케함</span></strong></p></td></tr></tbody></table> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong>위 표에서 처럼<span> Group 3</span>인<span> Memantine + Vitamine E </span>가<span> Group 2</span>인 </strong></span></p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><strong><span style="FONT-SIZE: 12pt">Memantine </span><span style="FONT-SIZE: 12pt">보다 효과가 낮은 이유는<span> Memantine </span>이<span> Vitamine E </span>의 </span></strong></p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong>항 산화 작용을 방해 하기 때문이라고 설명 하였다</strong></span></p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong>발표 자들은 비타민<span> E </span>은<span> Placebo </span>에 비해 년간 악화 방지를<span> 19% </span>지연 시켰으</strong></span></p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong>며 이는 증상 발현 을<span> 6 </span>개월 지연 시킴에 해당한다고 밝혔다</strong></span></p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><img width="488" height="203" style="WIDTH: 486px; HEIGHT: 395px" src="/_dimg/4%20imagesCARVEIGH.jpg"><a>\\\\</a></span></p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"></span> </p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"></span> </p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"></span> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong>모듡 종류의 사망률 및 부작용 발생율 은<span> Zero </span></strong></span></p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong>아래 표에서 처럼<span> 2,3</span>년 기간 중 나타난 사망 율 과 부 작용 발생 건 수는 </strong></span></p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><strong><span style="FONT-SIZE: 12pt">Group1 </span><span style="FONT-SIZE: 12pt">인<span> Vitamin E Group</span>에서는<span> Zero </span>였다 이는 상당 수의 여가지 질환 </span></strong></p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong>발병이 산화적 스트레스이므로 비타민<span> E</span>의 고량 요법에의한 고도의 항산화 작용</strong></span></p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong>이 많은 질환을 예방 할 수 있는 것으로 해석 할 수 있다</strong></span></p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <table width="650" style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; MARGIN: auto auto auto 14pt; WIDTH: 487.55pt; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" border="1" cellspacing="0" cellpadding="0"> <tbody> <tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" rowspan="2"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>사망 및</strong></span></p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><strong><span style="FONT-SIZE: 12pt"> </span><span style="FONT-SIZE: 12pt">부작용 발생</span></strong></p></td> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Group1 </strong></span></p></td> <td width="124" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 93.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Group2</strong></span></p></td> <td width="189" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 142pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Group3</strong></span></p></td> <td width="104" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Group4</strong></span></p></td></tr> <tr> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Vitamin E</strong></span></p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>2,000 IU</strong></span></p></td> <td width="124" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 93.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Memantine</strong></span></p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>20mg </strong></span></p></td> <td width="189" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 142pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Memantine 20mg</strong></span></p> <p style="TEXT-INDENT: 6pt; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Vitamin E 2,000 IU </strong></span></p></td> <td width="104" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>Placebo</strong></span></p></td></tr> <tr> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p></td> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><strong><span style="FONT-SIZE: 12pt">140 </span><span style="FONT-SIZE: 12pt">명</span></strong></p></td> <td width="124" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 93.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><strong><span style="FONT-SIZE: 12pt">142</span><span style="FONT-SIZE: 12pt">명</span></strong></p></td> <td width="189" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 142pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><strong><span style="FONT-SIZE: 12pt">139</span><span style="FONT-SIZE: 12pt">명</span></strong></p></td> <td width="104" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><strong><span style="FONT-SIZE: 12pt">140</span><span style="FONT-SIZE: 12pt">명</span></strong></p></td></tr> <tr> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>발생 자</strong></span></p></td> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>0</strong></span></p></td> <td width="124" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 93.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>23</strong></span></p></td> <td width="189" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 142pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>31</strong></span></p></td> <td width="104" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>11</strong></span></p></td></tr> <tr style="mso-yfti-irow: 4; mso-yfti-lastrow: yes"> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>발생 건수 </strong></span></p></td> <td width="116" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 87.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>0</strong></span></p></td> <td width="124" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 93.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>31</strong></span></p></td> <td width="189" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 142pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>44</strong></span></p></td> <td width="104" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 77.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #99ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; MARGIN: 0cm 0cm 0pt"><span style="FONT-SIZE: 12pt"><strong>13</strong></span></p></td></tr></tbody></table> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -12pt; MARGIN: 0cm 0cm 0pt 12pt"><span style="FONT-SIZE: 12pt"><img src="/_dimg/2-EC.gif"></span></p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong><font color="#ff0000" size="4">[그림] 비타민 E는 지질성 물질의 산화를 방지 하며 </font></strong></span></p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong><font color="#ff0000" size="4"> 비타민 C는 수용성 물질의 산화를 억제하나 </font></strong></span></p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong><font color="#ff0000" size="4"> 비타민 E 를 재활시키는 작용도한다</font></strong></span></p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong><font color="#ff0000" size="4"></font></strong></span> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong>비타민<span> E </span>의 알즈하이머 병 억제 효과</strong></span></p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><font size="5"><strong>뇌중에서도 인지 및 기억 세포는 산화 환원 반응이 활발한 곳이다</strong></font></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><font size="5"><strong>따라서 항산화 작용이 부족하면 과잉의 산화 반응이 </strong></font></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><font size="5"><strong>이들 세포를 파괴한다는 학설이 주창되어 왔었다 </strong></font></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><strong><font size="5"></font></strong> </p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><font size="5"><strong>해서 이미 오래 전부터 지질 계통의 항 산화 인자인 비타민<span> E </span>를 </strong></font></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><font size="5"><strong>알즈하이머 병 임상에 사용해왔다 그러나 통상 사용하는 량이 </strong></font></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><font size="5"><strong><span>400 IU </span>이하 였으므로 효과를 볼 수 없었다고 발표 자들은 설명했다 </strong></font></p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><strong><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></strong> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><strong><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></strong> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><strong><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></strong> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><strong><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></strong> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><strong><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><img width="515" height="230" style="WIDTH: 514px; HEIGHT: 372px" src="/_dimg/6%20glytamate%20untitled.bmp"></span></strong></p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><strong><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></strong> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><strong><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></strong> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><strong><span style="COLOR: #0000cc; FONT-SIZE: 18pt">Memantine</span><span style="COLOR: #0000cc; FONT-SIZE: 18pt">의 효과가 낮은 이유</span></strong></p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><strong><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></strong> </p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><font size="5"><strong>뇌에 많이 존재하는 신경 전달 물질인<span> Glutamate </span>의<span> NMDA </span>계 </strong></font></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><font size="5"><strong>수용체가 과잉 흥분 하면 기억 세포에 독 작용을 발휘한다는 </strong></font></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><font size="5"><strong>학설 하에 개발된<span> Glutamte </span>길항제가<span> Memantine</span>이다 </strong></font></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><strong><font size="5"></font></strong> </p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><font size="5"><strong>그러나 이 약에 대한 기초 임상에 부정적인 요소가 많했다고 </strong></font></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><font size="5"><strong>설명 하고 있다</strong></font></p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><strong></strong></span> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><span style="COLOR: #0000cc; FONT-SIZE: 18pt"><img width="524" height="227" style="WIDTH: 522px; HEIGHT: 392px" src="/_dimg/10%20%20donepezil%20%20-애ㅜㄷㅋuntitled.bmp"></span></p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><strong><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></strong> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><strong><span style="COLOR: #0000cc; FONT-SIZE: 18pt"></span></strong> </p> <p style="TEXT-INDENT: -18pt; MARGIN: 0cm 0cm 0pt 18pt"><strong><span style="COLOR: #0000cc; FONT-SIZE: 18pt">Donepezil<span> </span></span><span style="COLOR: #0000cc; FONT-SIZE: 18pt">과<span> Galantamie </span>의 경우</span></strong></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><span><strong><font size="5"></font></strong></span> </p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><strong><font size="5">알즈 하이머 병 자의 뇌에는 신경 전달 물질인<span> Acetylcholine</span>이</font></strong></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><strong><font size="5">모자라다는 학설하에<span> Acetylcholine<span> </span></span>파괴를 억제하는 물질을 </font></strong></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><strong><font size="5">개발한 것이 이 두 약물이다</font></strong></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><strong><font size="5"></font></strong> </p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><strong><font size="5">경증과 증등도에 사용하면 악화를 어느 정도 지연 시키므로</font></strong></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><strong><font size="5">현재 사용되고 있며 앞으로는 비타민<span> E </span>와 병용하는 것이 </font></strong></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><strong><font size="5">합리적이다 왜냐하면 알즈하이머 병은 그 원인이 미 해명 상태이므</font></strong></p> <p style="TEXT-INDENT: -14pt; MARGIN: 0cm 0cm 0pt 14pt"><strong><font size="5">로 가능한 한 메커니즘이 다른 약 끼리 병용 해야 하기 때문이다</font></strong></p> <p style="TEXT-INDENT: -28pt; MARGIN: 0cm 0cm 0pt 28pt"><span><strong><font size="5"></font></strong></span> </p> <p style="TEXT-INDENT: -28pt; MARGIN: 0cm 0cm 0pt 28pt"><strong><font size="5"><span>[</span>근거<span>]</span></font></strong></p> <p style="TEXT-INDENT: -28pt; MARGIN: 0cm 0cm 0pt 28pt"><span><strong><font size="5">JAMA. 2014;311(1):33-44. doi:10.1001/jama.2013.282834</font></strong></span></p> <p style="MARGIN: 0cm 0cm 0pt"><span><strong><font size="5">Original Investigation; Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial Maurice W. Dysken, MD1; Mary Sano, PhD2; Sanjay Asthana, MD3; Julia E. Vertrees, PharmD, BCPP4; Muralidhar Pallaki, MD5,6; Maria Llorente, MD7; Susan Love, MA1; Gerard D. Schellenberg, PhD8; J. Riley McCarten, MD1; Julie Malphurs, PhD9; Susana Prieto, MD9; Peijun Chen, MD, MPH, PhD5,6; David J. Loreck, MD10,11; George Trapp, MD, JD12; Rajbir S. Bakshi, MD12; Jacobo E. Mintzer, MD13,14,15; Judith L. Heidebrink, MD16; Ana Vidal-Cardona, MD17; Lillian M. Arroyo, MD17; Angel R. Cruz, MD18; Sally Zachariah, MD18; Neil W. Kowall, MD19; Mohit P. Chopra, MD19; Suzanne Craft, PhD20,21; Stephen Thielke, MD20,21; Carolyn L. Turvey, PhD22,23; Catherine Woodman, MD22,23; Kimberly A. Monnell, MD24; Kimberly Gordon, MSN, RN, FNP-BC24; Julie Tomaska, PhD1; Yoav Segal, MD, PhD1; Peter N. Peduzzi, PhD25,26; Peter D. Guarino, MPH, PhD25,26 </font></strong></span></p> <p style="MARGIN: 0cm 0cm 0pt"><span><a href="http://jama.jamanetwork.com/article.aspx?articleid=1810379"><span style="COLOR: windowtext; TEXT-DECORATION: none; text-underline: none"><strong><font size="5">[+-] Author Affiliations</font></strong></span></a></span><span><strong><font size="5"> </font></strong></span></p> <p style="MARGIN: 0cm 0cm 0pt"><span><strong><font size="5">1Minneapolis VA Health Care System, Minneapolis, Minnesota <br>2James J. Peters VA Medical Research Center, New York, New York <br>3William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin <br>4Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, New Mexico <br>5Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio <br>6Case Western Reserve University School of Medicine, Cleveland, Ohio <br>7Washington DC VA Medical Center, Washington, DC <br>8University of Pennsylvania School of Medicine, Philadelphia <br>9Miami VA Healthcare System, Miami, Florida <br>10VA Maryland Healthcare System, Baltimore <br>11University of Maryland Medical School, Department of Psychiatry, Baltimore <br>12VA North Texas Health Care System, Dallas <br>13Ralph H. Johnson VA Medical Center, Charleston, South Carolina <br>14Department of Health Studies, Medical University of South Carolina, Charleston <br>15Roper St Francis Healthcare, Charleston, South Carolina <br>16VA Ann Arbor Healthcare System, Ann Arbor, Michigan <br>17VA Caribbean Healthcare System, San Juan, Puerto Rico <br>18Bay Pines VA Healthcare System, Bay Pines, Florida <br>19VA Boston Healthcare System, Boston, Massachusetts <br>20VA Puget Sound Health Care System, Seattle, Washington <br>21Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle <br>22Iowa City VA Medical Center, Iowa City, Iowa <br>23University of Iowa, Iowa City <br>24W. G. (Bill) Hefner VA Medical Center, Salisbury, North Carolina <br>25Cooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven <br>26Yale University School of Public Health, New Haven, Connecticut </font></strong></span></p> <p style="TEXT-INDENT: -28pt; MARGIN: 0cm 0cm 0pt 28pt"><span><strong><font size="5"></font></strong></span> </p> 이전글다음글 목록
