섬유 근육 통 증후 군 의 통증을 현저히 개선 시키는 비타민 D > 최신 임상 뉴스

섬유 근육 통 증후 군 의 통증을 현저히 개선 시키는 비타민 D

페이지 정보

짧은주소

본문

섬유 근육 통 증후 군 의 통증을 
 
현저히 개선 시키는 비타민 D 
 
 
섬유 근육 통 환자가 비타민 D를 복용하여 혈중 농도를 증가시키면 
온 몸의 통 증이 현저하게 개선 된다는 사실이 밝혀졌다 
 
이는 오스트리아 비엔나 의대 연구 팀의 연구 결과이며
통증 저널 최근 호를 통해 발표 된 내용 이다 
 
 
섬유 근육 통(Fibromyalgia) 이란 
 
섬유 근육 통이란 원인 불명의 난치성 몸살 통이다 
아래 그림에서 처럼 몸 앞 쪽과 뒷 쪽 18군 데 중 
11군데 이상이 눌르면 아프다 하루 종일 몸살 통을 앓른다
아침에 기상하면 관절이 뻣뻣하고 
매우 피로하여 직장 생활이 어렵다
불면 증에 시달리고 불안 증과 우울 증을 지니기도한다
 
국민의 2-4%가 30-60세에서 발병하며 여자가 남자 보다 6-8배나 많다
치료하면 50%의 환자는 부분적으로 완화 될 뿐이다
 
<v:shapetype id="_x0000_t75" o:spt="75" coordsize="21600,21600" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f"><v:stroke joinstyle="miter"></v:stroke><v:formulas><v:f eqn="if lineDrawn pixelLineWidth 0"></v:f><v:f eqn="sum @0 1 0"></v:f><v:f eqn="sum 0 0 @1"></v:f><v:f eqn="prod @2 1 2"></v:f><v:f eqn="prod @3 21600 pixelWidth"></v:f><v:f eqn="prod @3 21600 pixelHeight"></v:f><v:f eqn="sum @0 0 1"></v:f><v:f eqn="prod @6 1 2"></v:f><v:f eqn="prod @7 21600 pixelWidth"></v:f><v:f eqn="sum @8 21600 0"></v:f><v:f eqn="prod @7 21600 pixelHeight"></v:f><v:f eqn="sum @10 21600 0"></v:f></v:formulas><v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect"></v:path><o:lock v:ext="edit" aspectratio="t"></o:lock></v:shapetype>
 
 
 
 
<img width="495" height="584" src="/_dimg/1-%20여인%20du20140217_182458.png">
[그림] 표시된 18군데 중 11군데 이상 통증ㅓㅇ  
 
 
 
비타민 D 복용 한 달 후 부터 통증 현저히 개선
 
혈중 농도 증가 할 수록 치료 효과 증가
 
 
 
섬유 근육 통 환자 30 명을 대상으로 하여 비타민 D 혈중 농도를
측정 하였던바 아래 표와 같았으며 임상 전 혈중 농도에 대응하여
비타민 D3 를 매일 표에 나타난 량을 25주간 복용 시켰다
 
<table width="669" style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; WIDTH: 501.55pt; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" border="1" cellspacing="0" cellpadding="0">
<tbody>
<tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes">
<td width="130" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 97.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid">
18 곳 중
15 곳 통증</td>
<td width="227" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 6cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid">
임상 전
VD 혈중 농도</td>
<td width="198" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 148.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid">
치료군 25주간 매일
VD3 복용
15 명</td>
<td width="113" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid">
대조군 
위약 복용
15명</td></tr>
<tr>
<td width="130" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 97.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffffcc; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
70% 환자</td>
<td width="227" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 6cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
평균 24ng/ml 이하</td>
<td width="198" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 148.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
2,400 IU</td>
<td width="113" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td></tr>
<tr style="mso-yfti-irow: 2; mso-yfti-lastrow: yes">
<td width="130" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 97.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffffcc; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
30% 환자</td>
<td width="227" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 6cm; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
평균24ng-32ng/ml</td>
<td width="198" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 148.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
1,200 IU</td>
<td width="113" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
 </td></tr></tbody></table>
 
 
 
 
 
<table style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" border="1" cellspacing="0" cellpadding="0">
<tbody>
<tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes">
<td width="102" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 76.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="113" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid">
 </td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid">
VD 혈중농도</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid">
VAS7 지수
섬유근통 지수</td></tr>
<tr>
<td width="102" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 76.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" rowspan="2">
1주 말</td>
<td width="113" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230">
대조군</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffffcc; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
20.89</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
62.0</td></tr>
<tr>
<td width="113" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230">
치료군</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffffcc; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
19.90-</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
68.7</td></tr>
<tr>
<td width="102" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 76.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" rowspan="2">
5주 말</td>
<td width="113" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230">
대조군</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffffcc; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
22.8</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
71.8</td></tr>
<tr>
<td width="113" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230">
치료군</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffffcc; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
32.3</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
57.6</td></tr>
<tr>
<td width="102" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 76.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" rowspan="2">
13주 말</td>
<td width="113" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230">
대조군</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffffcc; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
28.21</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
61.1</td></tr>
<tr>
<td width="113" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230">
치료군</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffffcc; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
50.96</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
50.6</td></tr>
<tr>
<td width="102" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 76.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" rowspan="2">
25주 말</td>
<td width="113" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230">
대조군</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffffcc; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
33.99</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
64.5</td></tr>
<tr>
<td width="113" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230">
치료군</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffffcc; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
48.86</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
53.4</td></tr>
<tr>
<td width="518" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 388.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eeece1; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2" colspan="4">
25주이후는 비타민 D 투약을 중단하고 증상을 비교</td></tr>
<tr>
<td width="102" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 76.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" rowspan="2">
49주말</td>
<td width="113" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230">
대조군</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffffcc; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
26.31</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
55,2</td></tr>
<tr style="mso-yfti-irow: 11; mso-yfti-lastrow: yes">
<td width="113" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ddd9c3; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid; mso-background-themecolor: background2; mso-background-themeshade: 230">
VD중단</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffffcc; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
26.34</td>
<td width="151" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff33; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
55.2</td></tr></tbody></table>
 
 
섬유 근육 통 환자에게 1주 50,000IU 3개월 투약한 경우
치료 효과가 없었다는 보고가 5년 전 발표 되었었는 바 
(J.Clin. Rheumatol 2008 :14 12-6drWarner AE, Aenspiger SA.)]
이는 VD 혈중 농도가 평균 31.2 ng/ml 에 도달한 경우였으며 따라서 섬유 근육 통은 VD 혈중 농도가 40-50ng/ml에는
도달하여야 한다고 발표하였다
 
[근거]
PAIN®, 2014; 155 (2): 261 DOI: <a href="http://dx.doi.org/10.1016/j.pain.2013.10.002" target="_blank">10.1016/j.pain.2013.10.002</a>
Florian Wepner, Raphael Scheuer, Birgit Schuetz-Wieser, 
Peter Machacek, Elisabeth Pieler-Bruha, Heide S. Cross, Julia Hahne, 
Martin Friedrich. Effects of vitamin D on patients with fibromyalgia syndrome:
 A randomized placebo-controlled trial.;
·Department of Orthopedic Pain Management, Spine Unit, 
Center of Excellence for Orthopaedic Pain Management, Speising, Vienna, Austria