지질 저 하제 Statin과 동시 병용하면 안 되는 약들 그리고 그 이유는 페이지 정보 전성수 0 짧은주소 × 짧은 글주소 복사 Note! 위 주소를 클릭 후, 복사(Ctrl+C)하여 사용하세요. 이전글다음글 목록 본문 <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: red; FONT-SIZE: 20pt">지질 저하제<span> Statin</span>과 동시 병용하면 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: red; FONT-SIZE: 20pt">안 되는 약들 그리고 그 이유는<span><span> </span></span></span></b></p> <p style="MARGIN: 0cm 0cm 10pt"> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"><img src="/_dimg/5%20drugs.jpg"></span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">지질 저하제 <span>Statin</span>과 동시에 복용하면 안 되는 약들이 매우 많다</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">이미 오래 전부터 약물 간 상호 작용 표를 통해</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">발표 되어 왔음에도 불구하고 </span></b><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">이 같은 잘 못된 동시 병용 처방 빈도가 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">미국에서도 매우 높다는 사실이 발표되었을 뿐 아니라 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">영국에서도<span> Statin</span>처방 중<span> 30%</span>가 잘 못 된 처방임이 밝혀 졌다</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">이는 영국 일반의의 처방을 대상으로 조사 분석한 결과이며</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">약품 안전 성 전문 지 최신 호를 통해 발표된 내용이다</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"><img width="587" height="278" style="WIDTH: 586px; HEIGHT: 358px" src="/_dimg/8%20factors.jpg"></span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: red; FONT-SIZE: 14pt">[</span></b><b><span style="LINE-HEIGHT: 115%; COLOR: red; FONT-SIZE: 14pt">그림<span>] </span>약물 상호 작용을 유발하는 여러 가지 인자들</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"> </p> <p style="MARGIN: 0cm 0cm 10pt"> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: red; FONT-SIZE: 20pt">Statin </span></b><b><span style="LINE-HEIGHT: 115%; COLOR: red; FONT-SIZE: 20pt">과 동시 처방 하면 안 되는 약들 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">지질 저하제<span> Staitn </span>중에서도 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">Atorvastati n</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">Simvastatin</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">Rousvastatin</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">Fluvastatin </span></b><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">등과 동시 병용하면 안 되는 약들은 다음과 같다</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <table style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" border="1" cellspacing="0" cellpadding="0"> <tbody> <tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <td width="615" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 461.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" colspan="2"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">병용하면<span> Statin </span>의 혈중 농도를 증가 시키는 약들</span></b></p></td></tr> <tr> <td width="158" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 118.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffccff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">약효군 </span></b></p></td> <td width="457" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 342.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffccff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Cyrtochrome P 450 3A4 </span></b><b><span style="FONT-SIZE: 14pt">억제 작용을 지닌 것 </span></b></p></td></tr> <tr> <td width="158" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 118.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">항균 제 </span></b></p></td> <td width="457" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 342.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Chloramphenicol</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Ciprofloxacin</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Clarithromycin</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Erythromycin</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Metronidazole</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Norfloxacin</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Quinine</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Telithrpmycin </span></b></p></td></tr> <tr> <td width="158" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 118.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">칼슘 길항제</span></b></p></td> <td width="457" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 342.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Diltiazem</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Mibefradil</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Verapamil</span></b></p></td></tr> <tr> <td width="158" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 118.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">항진균제</span></b></p></td> <td width="457" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 342.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Fluconazole </span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Itraconazole</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Ketorconazole</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Voriconazole </span></b></p></td></tr> <tr> <td width="158" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 118.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">진통제</span></b></p></td> <td width="457" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 342.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Propoxyphen</span></b></p></td></tr> <tr> <td width="158" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 118.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">산 분비 억제제</span></b></p></td> <td width="457" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 342.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Cimetidine</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Omeprazole</span></b></p></td></tr> <tr> <td width="158" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 118.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">항우울제</span></b></p></td> <td width="457" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 342.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Fluoxetine</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Fluvoxamine</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Nefazodoone</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Sertraline</span></b></p></td></tr> <tr> <td width="158" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 118.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">호르몬 제</span></b></p></td> <td width="457" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 342.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Danazole</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Mifefristone </span></b></p></td></tr> <tr> <td width="158" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 118.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">부정맥약 </span></b></p></td> <td width="457" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 342.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Amiodarone</span></b></p></td></tr> <tr> <td width="158" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 118.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">천식 약 </span></b></p></td> <td width="457" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 342.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Zafirlukast</span></b></p></td></tr> <tr> <td width="158" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 118.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">면역억제제</span></b></p></td> <td width="457" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 342.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Ciclosporin</span></b></p></td></tr> <tr> <td width="158" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 118.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">진토제</span></b></p></td> <td width="457" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 342.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Aprepitant</span></b></p></td></tr> <tr> <td width="158" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 118.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">항암제</span></b></p></td> <td width="457" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 342.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Anastozole</span></b></p></td></tr> <tr style="mso-yfti-irow: 14; mso-yfti-lastrow: yes"> <td width="158" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 118.8pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">에이즈 치료제 </span></b></p></td> <td width="457" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 342.4pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Amprenavir</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Atazanavir</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Darunavir</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Fasamprenavir</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Indinavir</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Lopinavir/Ritonvir</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Nelfinavir</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Ritonavir</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Saquinavir</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Tiprwanavir</span></b></p></td></tr></tbody></table> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"><img width="698" height="495" src="/_dimg/3%20clpt2006451f2.jpg"></span></b></p><b><span style="LINE-HEIGHT: 115%; COLOR: #0000cc; FONT-SIZE: 20pt"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: red; FONT-SIZE: 14pt">[</span></b><b><span style="COLOR: red; FONT-SIZE: 14pt">그림<span>] statin </span>약물 대사 억제 약물<span>(3A4 inhibitorA)</span>이 간에서 </span></b></p> <p style="LINE-HEIGHT: normal; TEXT-INDENT: 42pt; MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: red; FONT-SIZE: 14pt">statin </span></b><b><span style="COLOR: red; FONT-SIZE: 14pt">약물 대사 효소인 <span>3A4</span>를 억제하면<span> Statin </span>은 </span></b></p> <p style="LINE-HEIGHT: normal; TEXT-INDENT: 42pt; MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: red; FONT-SIZE: 14pt">간에서 대사되지 못한채 혈중 농도가 상승하여<span> </span></span></b></p> <p style="LINE-HEIGHT: normal; TEXT-INDENT: 42pt; MARGIN: 0cm 0cm 0pt"><b><span style="COLOR: red; FONT-SIZE: 14pt">근육에가서 근육을 파괴한다</span></b></p> <p style="TEXT-INDENT: 42pt; MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: red; FONT-SIZE: 14pt"></span></b> </p> </span></b><p style="MARGIN: 0cm 0cm 10pt"><b></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: #0000cc; FONT-SIZE: 20pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: #0000cc; FONT-SIZE: 20pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: #0000cc; FONT-SIZE: 20pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: #0000cc; FONT-SIZE: 20pt">병용하면 왜 안되나<span> ?</span></span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: #0000cc; FONT-SIZE: 20pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">모든 약물은 복용하면 간에서 약물 대사 효소에 의해 </span></b><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">대사를 받는다 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">약물마다 대사 효소가 다르다 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">지질 저하제<span> Statin </span>중 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">Atorvastatin</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">Simvastatin</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">등은<span> Cytochrom P450 3A4</span>라는 효소에 의해 대사를 받는다 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"><img src="/_dimg/2%20antifung_1.jpg"></span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">그러나 위 표에 열거된 약물들은 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">이<span> 3A4 </span>라는 약물 대사 효소의 작용을 억제하는 성질을 지니고 있다</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">따라서 이들을 함께 복용하면 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">간에서만 작용해야 할 <span>Statin </span>제제는 간에서 대사를 받지 못하고 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">혈중으로 유입되어 혈중농도가 상승하게 된다</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">Statin </span></b><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">의 혈중 농도가 상승하면 근 육속으로 침투하여</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">근육을 파괴<span>l</span>시켜 근육 통을 유발한다 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">드믄 경우이지만<span><span> </span></span>파괴된 근육이 신장을 파괴하여 사망케도 한다</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">이를 근융해증 <span>(Rhabdomyolysis) </span>이<span>; </span>라 한다 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"><img width="821" height="720" style="WIDTH: 696px; HEIGHT: 478px" src="/_dimg/11%20rhabdo.jpg"></span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">Statin </span></b><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">제제 중<span> Rousuvastatin<span> </span>Pravastatin, Fluvastatin</span>은 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">3A4 </span></b><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">효소에 의해 대사를 받지 않는 것으로 알려져 있으나</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">발표 자들은<span> 3A4 </span>효소 억제하는 약들과 병용하면 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">부작용을 유발 한다고 발표 하였다</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"><br></span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: #0000cc; FONT-SIZE: 20pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: #0000cc; FONT-SIZE: 20pt"><img width="655" height="258" style="WIDTH: 630px; HEIGHT: 225px" src="/_dimg/7%20drug%20i%20nter.jpg"></span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: #0000cc; FONT-SIZE: 20pt"><img width="670" height="517" style="WIDTH: 622px; HEIGHT: 463px" src="/_dimg/9%20PA145011109.png"></span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: #0000cc; FONT-SIZE: 20pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: #0000cc; FONT-SIZE: 20pt">Statin </span></b><b><span style="LINE-HEIGHT: 115%; COLOR: #0000cc; FONT-SIZE: 20pt">처방 의<span> 30%</span>가 잘 못된 병용 처방 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: #0000cc; FONT-SIZE: 20pt"></span></b> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">2008 </span></b><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">년<span> 1</span>년 동안 영국의 일반의 가 처방한 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">Statin </span></b><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">처방 환자는<span> 364,574qaud</span>이 였으며</span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">이 들 처방 중 잘못된 병용 처방 건수는 </span></b></p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt">아래 표처럼 무려<span> 30% </span>에 이른다</span></b></p> <table style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt" border="1" cellspacing="0" cellpadding="0"> <tbody> <tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <td width="196" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 147.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"> </p></td> <td width="416" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 311.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" colspan="2"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">2008</span></b><b><span style="FONT-SIZE: 14pt">냔<span> 1</span>년간 </span></b></p></td></tr> <tr> <td width="196" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 147.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"> </p></td> <td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">잘 못된 병용 처방</span></b></p></td> <td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">병용 처방 일수</span></b></p></td></tr> <tr> <td width="196" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 147.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Atorvastin</span></b></p></td> <td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">35.18%</span></b></p></td> <td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">205</span></b><b><span style="FONT-SIZE: 14pt">일 </span></b></p></td></tr> <tr> <td width="196" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 147.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Simvastatin </span></b></p></td> <td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">30.78%</span></b></p></td> <td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">194</span></b><b><span style="FONT-SIZE: 14pt">일</span></b></p></td></tr> <tr> <td width="196" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 147.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Simva/Ezetimibe</span></b></p></td> <td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">36.73%</span></b></p></td> <td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">197</span></b><b><span style="FONT-SIZE: 14pt">일 </span></b></p></td></tr> <tr> <td width="196" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 147.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Rousuvastatin </span></b></p></td> <td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">34.82%</span></b></p></td> <td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">192</span></b><b><span style="FONT-SIZE: 14pt">일</span></b></p></td></tr> <tr> <td width="196" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 147.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Pravastatin</span></b></p></td> <td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">36.97%</span></b></p></td> <td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">206</span></b><b><span style="FONT-SIZE: 14pt">일</span></b></p></td></tr> <tr style="mso-yfti-irow: 7; mso-yfti-lastrow: yes"> <td width="196" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 147.15pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">Fluvastatin</span></b></p></td> <td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">37.22%</span></b></p></td> <td width="208" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 155.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid"> <p align="center" style="TEXT-ALIGN: center; LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt">213</span></b><b><span style="FONT-SIZE: 14pt">일 </span></b></p></td></tr></tbody></table> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; FONT-SIZE: 14pt"></span></b> </p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"> </p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><img width="624" height="342" src="/_dimg/10%20Rhabdomyolysis4.jpg"></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"> </p> <p style="MARGIN: 0cm 0cm 10pt"><b><span style="LINE-HEIGHT: 115%; COLOR: red; FONT-SIZE: 14pt">[</span></b><b><span style="LINE-HEIGHT: 115%; COLOR: red; FONT-SIZE: 14pt">그림<span>] </span>근육 병태중 하나인 부종</span></b></p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"> </p> <p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt"><br>[</span></b><b><span style="FONT-SIZE: 14pt">근거<span>]</span></span></b></p> <p align="left" style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvTT250121a6">Pharmacoepidemiology and drug safety </span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvTT6120e2aa">2012; </span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: 'AdvTTb8864ccf.B'">21</span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvTT6120e2aa">: 485</span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvTT6120e2aa+20">–</span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvTT6120e2aa">493</span></b></p> <p align="left" style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvTT6120e2aa">Ameet Bakhai1,3*, Una Rigney2, Samuel Hollis2 and Cathy Emmas2 1</span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: 'AdvTT50a2f13e.I'">Barnet General Hospital, Wellhouse Lane, Barnet, London, UK </span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvTT6120e2aa">2</span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: 'AdvTT50a2f13e.I'">AstraZeneca UK, Luton, Bedfordshire, UK</span></b></p> <p align="left" style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 0pt"><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvTT6120e2aa">3</span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: 'AdvTT50a2f13e.I'">AMORE Health Ltd, Pinner, London, UK</span></b><b><span style="FONT-SIZE: 14pt; mso-bidi-font-family: AdvTT6120e2aa"></span></b></p> 이전글다음글 목록
