커피 마시면 파킨슨 병의 증상을 현저하게 치료해 준다 그 작용 원리는 ? 하루 몇 잔 마셔야하나? > 최신 임상 뉴스

커피 마시면 파킨슨 병의 증상을 현저하게 치료해 준다 그 작용 원리는 ? 하루 몇 잔 마셔야하나?

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커피 하루 두잔 마시면 
파킨슨 병의 증상을 현저하게 치료해 준다 
그 작용 원리는 ? 
 
 
<img width="534" height="285" style="WIDTH: 528px; HEIGHT: 629px" src="/_dimg/8%20imagesCAGYI6OP.jpg">
 
카페인을 단기간만 복용해도  
파킨슨  씨 병의 증상을 현저하게 개선시킨다는 사실이 밝혀졌다
 
이는 캐나다 토론토 의대 와 맥길 의대 연구팀의 연구 결과이며
미국 신경 학회 학술 지 최신 호를 통해 발표된 내용이다
 
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<img width="607" height="246" style="WIDTH: 606px; HEIGHT: 325px" src="/_dimg/그라프%202-1.png">
[그림] 3주째 현저히 개선되고 6주 째도 계속 개선되고 있다
좌측 : 파킨슨씨 병 증상 개선을 판단하는 모든 항목을 
종합한  개선 정도(정신 상태 일상 생할동작 튿수동작등)
우측: 임상 평가를 위한 특수 동작만을 종합한 개선 정도
 
 
 
<img width="639" height="391" style="WIDTH: 638px; HEIGHT: 491px" src="/_dimg/6%20dopamine-mao.jpg">
[그림] 파킨슨 씨병은 운동신경을 지배하는 신경 전달 불빌
Dopamine이 부족해지는 병이다 커피는 이 도파민을 증가시킨다
 
 
카페인 복용 3주 째는 현저히 개선
 
파킨슨 씨 병 환자를 두 그릅으로 나누고
Caffeine 복용 군 과 Placebo 복용군에대한 비교 임상을 실시했다
 
첫 3 주간은 카페인을 하루 2회 복용 
1회 카페인100mg 씩(커피 한잔 에 해당)을 아침에 한번 정심 때 한번 복용케 했다
 
다음 3주간은 카페인을 하루 2회 복용 1회 200mg 씩(커피 두 잔에 해당)을
아침에 한번 정심 때 한번 복용케 했다 
 
그  결과는 아래 표에서 처럼
카페인 복용 군은 3주째 부터 
파킨슨 씨병의 제반 동작 병태 증상이 현저하게 개선 되었음을 볼 수 있다
 
 
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<tbody>
<tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes; mso-row-margin-left: 1.7pt; mso-row-margin-right: .9pt">
<td width="2" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 0cm; PADDING-RIGHT: 0cm; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8">
 </td>
<td width="291" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 218.05pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" colspan="2">
 </td>
<td width="161" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 120.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid">
첫 3주간</td>
<td width="164" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 122.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid">
후 3 주간</td>
<td width="1" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 0cm; PADDING-RIGHT: 0cm; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8">
 </td></tr>
<tr style="mso-yfti-irow: 1; mso-row-margin-left: 1.7pt; mso-row-margin-right: .9pt">
<td width="2" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 0cm; PADDING-RIGHT: 0cm; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8">
 </td>
<td width="291" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 218.05pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
 </td>
<td width="161" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 120.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
아침 점심
카페인 100mg씩</td>
<td width="164" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 122.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
아침 정심
Placebo 복용</td>
<td width="1" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; PADDING-LEFT: 0cm; PADDING-RIGHT: 0cm; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8">
 </td></tr>
<tr style="mso-yfti-irow: 2; mso-row-margin-left: 1.7pt; mso-row-margin-right: .9pt">
<td width="2" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8; mso-border-bottom-themecolor: text1">
 </td>
<td width="291" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 218.05pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
임상 동작 (UPDRS III)</td>
<td width="161" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 120.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
-2.96</td>
<td width="164" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 122.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
-3.15</td>
<td width="1" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8; mso-border-bottom-themecolor: text1">
 </td></tr>
<tr>
<td width="57" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 42.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ffc000; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" rowspan="6" colspan="2">
 </td>
<td width="236" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 177.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
휴식 시 전율 상태</td>
<td width="161" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 120.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
-0.32</td>
<td width="165" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 123.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
-0.28-</td></tr>
<tr>
<td width="236" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 177.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
동작 시 전율 상태 </td>
<td width="161" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 120.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
-0.11</td>
<td width="165" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 123.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
-0.13</td></tr>
<tr>
<td width="236" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 177.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
동작 이완 상태 </td>
<td width="161" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 120.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
-0.97</td>
<td width="165" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 123.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
-1.70</td></tr>
<tr>
<td width="236" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 177.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
사지 이완상태 </td>
<td width="161" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 120.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
-0.88</td>
<td width="165" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 123.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
-1.22</td></tr>
<tr>
<td width="236" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 177.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
근육 강직 상태 </td>
<td width="161" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 120.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
-1.25</td>
<td width="165" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 123.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
-1.01</td></tr>
<tr>
<td width="236" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 177.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
걸음 걸이 상태 </td>
<td width="161" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 120.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
-0.12</td>
<td width="165" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 123.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
-0.28</td></tr>
<tr>
<td width="293" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 219.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="3">
동작 장애 (UPDRS IV)</td>
<td width="161" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 120.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
0.04</td>
<td width="165" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 123.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
0</td></tr>
<tr>
<td width="293" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 219.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="3">
동요 (UPDRSIV) </td>
<td width="161" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 120.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
-0.07</td>
<td width="165" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 123.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
-0.41</td></tr>
<tr style="mso-yfti-irow: 11; mso-yfti-lastrow: yes">
<td width="293" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 219.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="3">
종합  평가 지수 (Total UPDRS)</td>
<td width="161" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 120.5pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid">
-3.69</td>
<td width="165" style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ece9d8; PADDING-LEFT: 5.4pt; WIDTH: 123.55pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ece9d8; BORDER-RIGHT: black 1pt solid" colspan="2">
-4.69</td></tr>
<tr>
<td width="2" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"></td>
<td width="54" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"></td>
<td width="236" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"></td>
<td width="161" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"></td>
<td width="164" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"></td>
<td width="1" style="BORDER-BOTTOM: #ece9d8; BORDER-LEFT: #ece9d8; BACKGROUND-COLOR: transparent; BORDER-TOP: #ece9d8; BORDER-RIGHT: #ece9d8"></td></tr></tbody></table>
 
 
 
 
<img width="735" height="413" src="/_dimg/4%20adenosine2.jpg">
그림] 카페인은 Adenosun 수용체에 작용하여 Dopamine 을 증가
 
 
<img width="659" height="170" style="WIDTH: 658px; HEIGHT: 311px" src="/_dimg/3%20imagesCAY1RZ3L.jpg">
 
<img width="687" height="414" style="WIDTH: 686px; HEIGHT: 514px" src="/_dimg/7%201-s2_0-S0024320509002550-gr10.jpg">
[그림] 카페인은 Adenosun 수용체에 작용하여 Dopamine 을 증가
 
 
Caffeine  의 약효 원리
 
파킨슨 씨병은 운동 신경 전달 물질인 
Dopamine 의 작용이 감소하는 병이다
 
Caffeine 은 뇌의 Dopamine 인접 부위에 존재하는 
Adenosine 수용체에 작용하여 Dopamine 을 증가시킨다고 발표자들은 설명 하고 있다
 
[근거]
Neurologuy 79 August  14 2012
Caffeine for treatment of Parkinson disease
A randomized controlled trial
Ronald B. Postuma, MD, MSc et al: 
Department of Neurology  McGill University, Montreal
University of Toronto, Toronto, Canada;