갑상선 호르몬 제 Levothyroxine 이 노인들에게 골절을 유발하는 이유 와 대책 페이지 정보 전성수 0 짧은주소 × 짧은 글주소 복사 Note! 위 주소를 클릭 후, 복사(Ctrl+C)하여 사용하세요. 이전글다음글 목록 본문 <TABLE class=tbl2> <TBODY> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD class=tbl2-title> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt; mso-outline-level: 3" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 20pt">갑상선 호르몬 제 <SPAN>Levothyroxine </SPAN>이</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 20pt">노인들에게 골절을 유발하는 이유 와 대책</SPAN></B></P></TD></TR> <TR style="HEIGHT: 35.15pt; mso-yfti-irow: 1; mso-yfti-lastrow: yes"> <TD class=tbl2-contents> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">갑상선 호르몬제제<SPAN> Levothyroxine </SPAN>을 복용하고 있는</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">노년층 중 무려<SPAN> 10.4%</SPAN>가 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">골절을 유발하고 있다는 중대한 사실이 밝혀졌다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">복용량이 많은 자일 수록 비례해서</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">골절 발생이<SPAN> 3.4</SPAN>배나 더 증가한다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">6</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">개월 전까지 복용했던 자 보다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">현재 복용하고 있는 자가</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">2 </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">배나 더 골절률이 높다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="FONT-SIZE: 14pt"><BR></SPAN></B> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이는 캐나다<SPAN> Toronto </SPAN>의대 연구 팀의 분석 결과이며 <BR></SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">영국 의사회 학술지<SPAN> BMJ </SPAN>통해 </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">그 이유와 예방책도 함께 발표된 것이다</SPAN></B></P></TD></TR> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD class=tbl2-subtitle> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 20pt">골절이 증가하는 이유</SPAN></B></P></TD></TR></TBODY></TABLE> <TABLE class=tbl2> <TBODY> <TR style="HEIGHT: 35.15pt; mso-yfti-irow: 1; mso-yfti-lastrow: yes"> <TD class=tbl2-contents> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">갑상선 호르몬은 나이 들수록 분비량이 감소된다<BR></SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">때문에 노인 중<SPAN> 20%</SPAN>가 갑상선 기능이 저하되었다 하여</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"><BR> </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">갑상선 호르몬<SPAN> Levothyroxine </SPAN>을 투약 받기 시작한다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">그리고 계속해서 동일 용량을 복용한다 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">그러나 분비된 갑상선 호르몬이나 복용한 갑상선 호르몬이 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">체내에서 대사되어 배설되는 속도는 </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">나이가 들수록 점점 느려져 간다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">따라서 노인들이 매일 복용하는<SPAN> Levothyroxine </SPAN>량을</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">감량하지 않고 계속 복용하면</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">날이 갈수록 노인에게는 과량이 되어간다 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"><BR> 해서 별 다른 증상은 없지만 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">만성적 갑상선 기능 과대 증으로 변하게 된다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">갑상선 기능 과잉인 상태에서는 </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">음파 검사하면 골 밀도가 저하되어 있고</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">골 구조가 질적으로 변질 된다<SPAN> </SPAN></SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">부정맥이 발생 한다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">근육 신경 장애로 인해 근력이 감소하고</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">골 밀도와 무관하게 낙상 빈도가 증가한다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"><BR></SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"><IMG src="/_dimg/1%20척추.bmp"> </SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"><IMG src="/_dimg/2%20골밀도.bmp"></SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">[</SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">그림<SPAN>]</SPAN>갑상선 호르몬은 심장과 간과 뼈와 중추 신경에서 </SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">대사 속도를 </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">가속화시키는 작용을 한다<SPAN>. </SPAN>모든 것을 불로 태우는 </SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">작용이다<SPAN>. </SPAN>즉 에너지를 일시에 소모시키는 작용이다.</SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">필요 없이 발열을 일으키고 맥을 급히 뛰게 하는 등 </SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: red; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: red; FONT-SIZE: 14pt">이러한 파괴작용의 일한으로 뼈도 파괴 된다 </SPAN></B></P></TD></TR> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD class=tbl2-subtitle> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 20pt">20%</SPAN></B><B><SPAN style="COLOR: blue; FONT-SIZE: 20pt">가 과대 처방 </SPAN></B></P></TD></TR></TBODY></TABLE> <TABLE class=tbl2> <TBODY> <TR style="HEIGHT: 35.15pt; mso-yfti-irow: 1; mso-yfti-lastrow: yes"> <TD class=tbl2-contents> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">성인의 최적 용량은 하루<SPAN> 1.6-1.8 mcg/kg </SPAN>이지만</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">65</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">세 이상은 성인 용량의<SPAN> 1/3 </SPAN>만으로 충분하다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">그러나 아래 표에서처럼 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">처방자의<SPAN> 20%</SPAN>가 성인 용량에는 적합하지만</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">실제로는 과잉 처방되고 있음이 밝혀졌다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <TABLE style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184" border=1 cellSpacing=0 cellPadding=0 table> <TBODY> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 153.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" width=205> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Levothyroxine </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">1 </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">일 용량</SPAN></B></P> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center> </P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 276.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" width=369> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">성인의 최적 용량은 하루<SPAN> 1.6-1.8 mcg/kg </SPAN>이지만</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">65</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">세 이상은 성인 용량의<SPAN> 1/3 </SPAN>만으로 충분하다</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 153.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">성인</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 276.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=369> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">1.6-1.8 </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">μ<SPAN>g/kg</SPAN></SPAN></B></P></TD></TR> <TR style="mso-yfti-irow: 2; mso-yfti-lastrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 153.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">65</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">세 이상</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 276.95pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=369> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 98pt; MARGIN: 0cm 0cm 0pt; mso-char-indent-count: 7.0" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">0.5 </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">μ<SPAN>g/kg</SPAN></SPAN></B></P></TD></TR></TBODY></TABLE></TD></TR> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD class=tbl2-subtitle> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 20pt">용량 높은 자는<SPAN> 3.4</SPAN>배의 골절률</SPAN></B></P></TD></TR> <TR style="HEIGHT: 35.15pt; mso-yfti-irow: 1; mso-yfti-lastrow: yes"> <TD class=tbl2-contents> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Levothyroxine</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">을 복용하는 자를 대상으로 하여<BR></SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">3,4</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">년간 골절 발생을 분석한 결과 아래 표에서와 같이</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"><BR> 10.4%</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">가 골절을<SPAN> 1</SPAN>회 이상 발생시켰다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <TABLE style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; MARGIN: auto auto auto 26.7pt; WIDTH: 361.45pt; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184" border=1 cellSpacing=0 cellPadding=0 width=482 table> <TBODY> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 361.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" width=482 colSpan=2> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Levothyroxine </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">복용 자 골절률</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">복용 자</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 8cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=302> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">213,511 </SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">명<SPAN> (</SPAN></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">75-105</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">세<SPAN>)</SPAN></SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt"></SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=180> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">현재 복용 자</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 8cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=302> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">20.514</SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">명</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 134.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" rowSpan=2 width=180> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">골절 발생</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 8cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=302> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">22.236</SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">명<SPAN>(10.4%)</SPAN></SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 8cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=302> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">여성<SPAN> (</SPAN></SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">18,108</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">명<SPAN>=88%)</SPAN></SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt"></SPAN></B></P></TD></TR> <TR style="mso-yfti-irow: 5; mso-yfti-lastrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 361.45pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=482 colSpan=2> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">2002</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">년<SPAN> 4</SPAN>월<SPAN>1</SPAN>일<SPAN> ~ 2007</SPAN>년<SPAN> 3</SPAN>월<SPAN> 31</SPAN>일<SPAN> (3.8</SPAN>년<SPAN>) </SPAN></SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">캐나다 토론토 의대 분석<SPAN> (</SPAN>지역 국민 전체 분석<SPAN>) </SPAN></SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt"></SPAN></B></P></TD></TR></TBODY></TABLE> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">아래 표에서처럼 </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">현재 복용 자 중에서 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; TEXT-INDENT: 7pt; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">고용량 복용 군의 골절 발생이 저용량 복용 군 보다<SPAN> 3.4</SPAN>배나 높다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt"></SPAN></B> </P> <TABLE style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; WIDTH: 508.65pt; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184" border=1 cellSpacing=0 cellPadding=0 width=678 table> <TBODY> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 508.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" width=678 colSpan=4> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">현재 복용 중인 자의 용량 별 골절률</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 111.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=149> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center> </P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=151> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">고용량 군</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">중등도 용량 군</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">저용량 군</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 111.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=149> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">복용 자 수</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=151> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">31.8%</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">53.2%</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">15%</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 111.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=149> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">1</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">일 평균 복용</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=151> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">0.093 mg</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이하</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">0.044-0.093 mg</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">0.044 mg </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이상</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 111.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=149> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">1</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">년 간</SPAN></B></P> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">총 복용량</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=151> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">34mg </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이상 </SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">16mg - 34mg</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">16mg </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">이하 </SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 111.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=149> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">골절 위험</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=151> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">3.45</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">2.62</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">1</SPAN></B></P></TD></TR> <TR style="mso-yfti-irow: 6; mso-yfti-lastrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 508.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=678 colSpan=4> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">한국 허가 유지 용량<SPAN>: levothyroxine<SPAN> </SPAN></SPAN>유지 용량<SPAN> 1</SPAN>일<SPAN> 0.1mg-0,4mg </SPAN></SPAN></B></P></TD></TR></TBODY></TABLE> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <TABLE style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; WIDTH: 508.65pt; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184" border=1 cellSpacing=0 cellPadding=0 width=678 table> <TBODY> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 508.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" width=678 colSpan=4> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">현재 복용 자<SPAN>, 15</SPAN>일전 중단 자<SPAN>, 6</SPAN>개월전 중단 자</SPAN></B></P> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">골절률</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 111.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=149> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">골절부위</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=151> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">현재복용</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">15</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">일전 중단</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #f2f2f2; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">6</SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">개월 전 중단</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 111.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=149> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">모든 부위</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=151> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">1.88</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">1.31</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">1,00</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 111.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=149> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">엉덩이</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=151> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">1.58</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">1.09</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 5cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=189> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">1,00</SPAN></B></P></TD></TR> <TR style="mso-yfti-irow: 4; mso-yfti-lastrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 508.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ff99ff; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=678 colSpan=4> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">한국 허가 유지 용량<SPAN>: levothyroxine </SPAN>유지 용량<SPAN> 1</SPAN>일<SPAN> 0.1mg-0,4mg </SPAN></SPAN></B></P></TD></TR></TBODY></TABLE></TD></TR> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD class=tbl2-subtitle> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 20pt">남자는 고용량을 복용하는 경우</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 20pt"><BR>골절률이 급격하게 증가한다</SPAN></B></P></TD></TR> <TR style="HEIGHT: 35.15pt; mso-yfti-irow: 1; mso-yfti-lastrow: yes"> <TD class=tbl2-contents> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">모든 골절 환자 중 여자가<SPAN> 88%</SPAN>를 차지하고 있다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">그러나 남자는 여자보다 용량 증가에 따른</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">골절 증가율이 급격히 증가한다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <TABLE style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184" border=1 cellSpacing=0 cellPadding=0 table> <TBODY> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 461.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" width=615 colSpan=3> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">모든 골절 발생 비교 위험률</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 153.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eaf1dd; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center> </P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eaf1dd; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">남자</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eaf1dd; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">여자</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 153.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">저용량 군</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">1.42</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">1.98</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 153.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">중등도 용량 군</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">3.18</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">2.56</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 153.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">고용량 군</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">4.07</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">3.31</SPAN></B></P></TD></TR> <TR style="mso-yfti-irow: 5; mso-yfti-lastrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 461.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=615 colSpan=3> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">팔과 팔목<SPAN>, </SPAN>어깨<SPAN>, </SPAN>흉골<SPAN>, </SPAN>요추<SPAN>, </SPAN>골반<SPAN>, </SPAN>대퇴골<SPAN>, </SPAN>하지<SPAN>, </SPAN>발목</SPAN></B></P></TD></TR></TBODY></TABLE> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <TABLE style="BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; BORDER-COLLAPSE: collapse; BORDER-TOP: medium none; BORDER-RIGHT: medium none; mso-yfti-tbllook: 1184" border=1 cellSpacing=0 cellPadding=0 table> <TBODY> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 461.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid" width=615 colSpan=3> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Hip </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">골절 발생 비교 위험률</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 153.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eaf1dd; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center> </P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eaf1dd; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">남자</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #eaf1dd; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">여자</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 153.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">저용량 군</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">1.14</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">1.65</SPAN></B></P></TD></TR> <TR> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 153.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">중등도 용량 군</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">3.12</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">2.46</SPAN></B></P></TD></TR> <TR style="mso-yfti-irow: 4; mso-yfti-lastrow: yes"> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 153.7pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">고용량 군</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">5.05</SPAN></B></P></TD> <TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 153.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid" width=205> <P style="TEXT-ALIGN: center; LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=center><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">3.19</SPAN></B></P></TD></TR></TBODY></TABLE></TD></TR> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"> <TD class=tbl2-subtitle> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: blue; FONT-SIZE: 20pt">주기적으로 처방 량 조정이 절대 필요</SPAN></B></P></TD></TR> <TR style="HEIGHT: 35.15pt; mso-yfti-irow: 1; mso-yfti-lastrow: yes"> <TD class=tbl2-contents> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">노년층은<SPAN> Levothyroxine </SPAN>대사 속도가 계속 느려지므로 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">용량 감소 필요성 여부를</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">골밀도 조사와 함께 주기적으로 검토해야 한다</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">한편<SPAN> Levothyroxine</SPAN>은 <BR></SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">안전역 범위가 매우 좁을 뿐 아니라</SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">흡수율이 매우 낮으므로 </SPAN></B></P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left> </P> <P style="LINE-HEIGHT: 150%; MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt"> </SPAN></B><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">필히 아침 식사 한 시간 전 공복 시에 복용할 것 을 강조해야 한다</SPAN></B></P></TD></TR></TBODY></TABLE> <TABLE class=tbl2> <TBODY> <TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes; mso-yfti-lastrow: yes"> <TD class=tbl2-ref1> <P style="MARGIN: 0cm 0cm 0pt"><B><SPAN style="FONT-SIZE: 14pt">근거</SPAN></B></P></TD> <TD class=tbl2-ref2> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">BMJ 2011; 342:d2238 doi: 10.1136/bmj.d2238 (Published 28 April 2011) Cite this as: BMJ 2011; 342:d2238</SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt"></SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt; mso-outline-level: 2" align=left><B><SPAN style="COLOR: black; FONT-SIZE: 14pt">Levothyroxine dose and risk of fractures in older adults: nested case-control study; </SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A href="http://www.bmj.com/search?author1=Marci+R+Turner&sortspec=date&submit=Submit"><SPAN style="COLOR: #333333; TEXT-DECORATION: none; mso-bidi-font-weight: bold; text-underline: none">Marci R Turner</SPAN></A></SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">, </SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A href="http://www.bmj.com/search?author1=Ximena+Camacho&sortspec=date&submit=Submit"><SPAN style="COLOR: #333333; TEXT-DECORATION: none; mso-bidi-font-weight: bold; text-underline: none">Ximena Camacho</SPAN></A></SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">, </SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A href="http://www.bmj.com/search?author1=Hadas+D+Fischer&sortspec=date&submit=Submit"><SPAN style="COLOR: #333333; TEXT-DECORATION: none; mso-bidi-font-weight: bold; text-underline: none">Hadas D Fischer</SPAN></A></SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">, </SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A href="http://www.bmj.com/search?author1=Peter+C+Austin&sortspec=date&submit=Submit"><SPAN style="COLOR: #333333; TEXT-DECORATION: none; mso-bidi-font-weight: bold; text-underline: none">Peter C Austin</SPAN></A></SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">, </SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A href="http://www.bmj.com/search?author1=Geoff+M+Anderson&sortspec=date&submit=Submit"><SPAN style="COLOR: #333333; TEXT-DECORATION: none; mso-bidi-font-weight: bold; text-underline: none">Geoff M Anderson</SPAN></A></SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">, , </SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A href="http://www.bmj.com/search?author1=Paula+A+Rochon&sortspec=date&submit=Submit"><SPAN style="COLOR: #333333; TEXT-DECORATION: none; mso-bidi-font-weight: bold; text-underline: none">Paula A chon</SPAN></A></SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">,</SPAN></B><B><SPAN style="FONT-SIZE: 14pt"><A href="http://www.bmj.com/search?author1=Lorraine+L+Lipscombe&sortspec=date&submit=Submit"><SPAN style="COLOR: #333333; TEXT-DECORATION: none; mso-bidi-font-weight: bold; text-underline: none">Lorraine L Lipscombe</SPAN></A></SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">, ;</SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt"></SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SUP><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">1</SPAN></SUP></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">Department of Medicine, University of Toronto, Canada </SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">Institute for Clinical Evaluative Sciences, Toronto, Canada </SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">Department of Health Policy Management and Evaluation, University of Toronto, Canada </SPAN></B></P> <P style="MARGIN: 0cm 0cm 0pt" align=left><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">Women</SPAN></B><B><SPAN style="COLOR: #333333; FONT-SIZE: 14pt">’<SPAN>s College Research Institute, 790 Bay Street, Toronto, ON, Canada M5G 1N8 </SPAN></SPAN></B></P></TD></TR></TBODY></TABLE> <STYLE type=text/css> .tbl2 { border: windowtext 1pt solid; width: 790px; border-collapse: collapse; border-top: medium none; border-right: medium none; } .tbl2-title { padding: 30px; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; width: 790px; background: aqua; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; vertical-align: middle; } .tbl2-left { border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; width: 20px; background: #fabf8f; border-top: #ece9d8; border-right: windowtext 1pt solid; } .tbl2-contents { padding: 30px; border-bottom: windowtext 1pt solid; border-left: #ece9d8; width: 790px; background: #fde9d9; border-top: #ece9d8; border-right: windowtext 1pt solid; vertical-align: middle; } .tbl2-subtitle { padding: 30px; border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; background: aqua; border-top: #ece9d8; border-right: windowtext 1pt solid; vertical-align: middle; } .tbl2-ref1 { border-bottom: windowtext 1pt solid; border-left: windowtext 1pt solid; width: 80px; background: #d9d9d9; border-top: windowtext 0pt solid; border-right: windowtext 1pt solid; vertical-align: middle; text-align: center; } .tbl2-ref2 { padding: 30px; border-bottom: windowtext 1pt solid; border-left: #ece9d8; background: #f2f2f2; border-top: windowtext 0pt solid; border-right: windowtext 1pt solid; vertical-align: middle; } </STYLE> 이전글다음글 목록
