Tamsulosin 단 1회 복용 할 때마다 남성 피임 할 수 있다 그 작용 원리는? 복용 방법은 > 복약 지도

Tamsulosin 단 1회 복용 할 때마다 남성 피임 할 수 있다 그 작용 원리는? 복용 방법은

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Tamsulosin 단 1회 복용 할 때마다 
남성 피임 할 수 있다
그 작용 원리는? 복용 방법은 ?</TD></TR>
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Tamsulosin 은  전립선 비대 증에  배뇨 장애 치료 제로 사용되는 약이다
 
그러나 남성이 필요 할 때 마다 단 1회 만 복용하면 
그 때만 피임 할 수 있다는 놀라운 사실이 밝혀졌다
 
약을 사용 안 하면 임신 할 수 있으며 단 1 회 복용이므로 부작용 문제도 없다
 
이는 중국 산동 제낭(Ji’nan)의대 연구 팀의 연구 결과이며
비뇨기 학 학술지 최신 호를 통해 밝혀진 내용이다
 
<IMG src="/_dimg/2-1%20고환%2020141203_155800.png">
[그림] Tamsulosin 은 정자관(Vas deferens)에서 정자가 나오지 못하게하고
         정랑(Seminal vesicle)에서 정액이 사출 되지 않게한 
 </TD></TR></TBODY></TABLE>
 
 
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행위 4-6 시간 전에 한 번 만  복용</TD></TR>
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Tamsulosin 0.8mg  을 행위 4-6 시간 전에 단 한번만 복용하면
복용 자는 모두가 정자를 함유한 정액 을 완전하게 사출 하지 않는다
 
그러나 약을 복용 치 아니하면 다시 정액을 사출 할 수</TD></TR></TBODY></TABLE>
 
 
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Tamsulosin  0,8mg 는 100% 효과 발휘하지만
0.4mg  는 불 완전 하다</TD></TR>
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본 임상은 22세-31세의 중국인 남성 40명을 두 그릅으로 나누고
아래 표와 같이 Placebo 와  Tamsulosin 0,4mg 와 0.8mg 를 
교차 복용시키는 비교임상을 실시하였다
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1차 조사</TD>
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2차조 사</TD>
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3조사</TD>
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4차조 사</TD>
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5차조 사</TD></TR>
<TR >
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GroupA</TD>
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대조 약</TD>
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7일간휴약 </TD>
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0.4mg </TD>
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7일간휴약</TD>
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0.8mg </TD></TR>
<TR >
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 76.3pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=102>
GroupB</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 70.85pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=94>
0.8mg</TD>
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7일간휴약</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 63.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=85>
0.4mg </TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 70.9pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=95>
7일간휴약</TD>
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대조 약 </TD></TR>
<TR >
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자위행위 </TD>
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투약 후 4-6시간 내 자위행로 사정케 하여 조사 </TD></TR>
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휴약 기간 중에도 1회 사정케하여 조사</TD></TR>
<TR >
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재확인 </TD>
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정자가 발견되지 않은 자는 사출 후 배뇨 시켜 
중간 배뇨 액 중의 정자 여부를 검사 </TD></TR>
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금지 </TD>
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투약 전 3일간은 자위행위나 성행위 금지</TD></TR>
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사출 후 정자 검사 전 사출 행위 금지</TD></TR>
<TR style="mso-yfti-irow: 8; mso-yfti-lastrow: yes">
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검사기 </TD>
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정자 분석 기 :SPSS 16.0 (IBM, Armonk, NY).</TD></TR></TBODY></TABLE>
 
이상 과 같은 방식으로 조사한 결과 
아래 표에서와 같이
0.8mg 복용 자는 전원 정액이 사출되지 안 했으나
0.4mg 복용 자는  Placeb0를 복용한 자 만큼 
2.88mL 의 정액을 사출 했으며 이중에  함유된 정자 수는 무려 55,950,000 였다 
 
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 </TD>
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정액 량 (mL)</TD>
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1mL 중 정상 기능 정자 수 </TD></TR>
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임상 전 상태</TD>
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3.30</TD>
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70,290,000</TD></TR>
<TR >
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0.8mg 투약 후</TD>
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Zero</TD>
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zero</TD></TR>
<TR >
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1차 휴악 중 </TD>
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3.75</TD>
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78.800,000</TD></TR>
<TR >
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0.4mg,투약 후 </TD>
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2.88</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 163.05pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #66ff66; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=217>
55,950.000</TD></TR>
<TR >
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2차 휴약 기간중 </TD>
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3.75</TD>
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69,840,000</TD></TR>
<TR >
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대조약 투약 후 </TD>
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3.50</TD>
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68,130,000</TD></TR>
<TR style="mso-yfti-irow: 7; mso-yfti-lastrow: yes">
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 111.75pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=149>
최종 완료후  </TD>
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3.60</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 163.05pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=217>
68,540,000</TD></TR></TBODY></TABLE>
 
 
<IMG src="/_dimg/2-2%20정자%2020141203_155858.png">
[그림] 정액(semen) 중에 보이는 정자들 : 평균 정액 1cc 당 
        3억개가 함유 되지만 정상적 기능을 지닌 정자는 
2천만개 이상만 함유 되면 임상 할수 있다
 
 </TD></TR></TBODY></TABLE>
 
 
 
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복용 안 하면 정액을 다시 사출</TD></TR>
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위 표에서 처럼 약을 복용 안 하는 동안은 다시 정액을 사출 할 수 있으며 
정액 량이나 정자순은 Placebo 군과 차이가 없다 </TD></TR></TBODY></TABLE>
 
 
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Tamsuosin 0.8mg  은
부작용 없는  안전한 1회용 남성 피임제이다</TD></TR>
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Tamsulosin 0.8mg 복용 자 40명 중에 나타난
부작용은 아래 표와 같아 3종류 만이 엇으며며 
이들 부작용은 복용 후 10시간 내에 살아 졌다
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<TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes">
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 267.65pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; " width=357 colSpan=2>
10시간 내 살아진 부작용들</TD></TR>
<TR >
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안검 하수</TD>
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1건</TD></TR>
<TR >
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콧물</TD>
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2건</TD></TR>
<TR style="mso-yfti-irow: 3; mso-yfti-lastrow: yes">
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피로감</TD>
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3건</TD></TR></TBODY></TABLE>
 
 
 </TD></TR></TBODY></TABLE>
 
 
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Tamsulosoin의 남성 피임 작용 원리</TD></TR>
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Tamsulosin은 알파 수용체인 1A 1B 1D 세가지 수용체를 
차단하는 알파 차단제이며 이들 수용체를 차단하므로서
뇨로를 확장시켜 전립선 비대 증의 배뇨 장애를 치료하는 약이다
 
그러나 알파 차단제 중에서도 tamsulosin 은 
알파 수용체 1A 에 대한 차단 작용이 강한 약물이다
 
이래 표에;서 처럼 알파 수용체 1A 는 전립선에도 많히 존재하지만
정액을 만들어 내는 정랑에도 많이 존재하고 
정자 관에도 매우 많이 존재한다 
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<TR style="mso-yfti-irow: 0; mso-yfti-firstrow: yes">
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 69.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; " width=92>
 </TD>
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알파 
1A 수용체 </TD>
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알파
1B 수용체 </TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #ccffff; BORDER-TOP: black 1pt solid; BORDER-RIGHT: black 1pt solid; " width=113>
알파
1D 수용체</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 69.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=92>
정 낭 </TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=151>
75%</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=132>
11.7%</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=113>
13.3%</TD></TR>
<TR >
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 69.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=92>
정자관 </TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=151>
97%</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=132>
0</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=113>
3%</TD></TR>
<TR style="mso-yfti-irow: 3; mso-yfti-lastrow: yes">
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: black 1pt solid; PADDING-LEFT: 5.4pt; WIDTH: 69.2pt; PADDING-RIGHT: 5.4pt; BACKGROUND: yellow; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=92>
전립선</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 4cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=151>
압도적 존재</TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 99.25pt; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=132></TD>
<TD style="BORDER-BOTTOM: black 1pt solid; BORDER-LEFT: #ffffff; PADDING-LEFT: 5.4pt; WIDTH: 3cm; PADDING-RIGHT: 5.4pt; BACKGROUND: #fde9d9; BORDER-TOP: #ffffff; BORDER-RIGHT: black 1pt solid; " width=113></TD></TR></TBODY></TABLE>
 따라서 알파 1A 수용체가 Tamsulosin에 의해 차단되면
정가 관이 막혀 정자가 나오지 못하고 정랑이 막혀 정액도 사출 되지 못한다
 
<IMG src="/_dimg/2-3%20수용체%2020141203_155949.png">
[그림] 알파차단제 중 남성 피임 작용을 발휘함이 입증된 약물은
알파1a 수용체를 가장 강력하게 차단하는 
Tawmsulosin 0.8mg 과 신약 Silosodin 이 있다
 </TD></TR></TBODY></TABLE>
 
 
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[근거]</TD></TR>
<TR style="mso-yfti-irow: 1; mso-yfti-lastrow: yes">
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Urology, July 31, 2012; Assessment of Tamsulosin as a Potential Male Contraceptive in Healthy Volunteers; Jin Wang et al;
the Department of Minimally Invasive Urology Center, Provincial Hospital Shandong University, Ji’nan, Shandong Province, China
God Bless you!
전성수</TD></TR></TBODY></TABLE>